COMTVal158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population

HM Aytac, Y Oyaci, PC Aydin, M Pehlivan… - Neurosciences …, 2022 - nsj.org.sa
Objectives: To investigate catechol-O-methyltransferase (COMT) Val158Met gene
polymorphism in MDMA use disorder (MUD) by comparing genotype distributions between …

The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with …

A Ermis, M Erkiran, S Dasdemir, AS Turkcan… - in vivo, 2015 - iv.iiarjournals.org
Background/Aim: One of the risk factors for increasing psychotic disorders is the use of
cannabis. It has been shown that the inactivation of dopamine and other catecholamines …

[HTML][HTML] No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data

C Tovilla-Zárate, I Juárez-Rojop, T Ramón-Frias… - BMC psychiatry, 2011 - Springer
Abstract Background The polymorphism COMTval158met has been associated with suicidal
behavior in case-control and meta-analysis studies, but results and conclusions remain …

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence

G Nedic, M Nikolac, KN Sviglin… - International journal …, 2011 - academic.oup.com
Alcohol dependence is frequently associated with aggressive and suicidal behaviour.
Genetic factors contribute to both behaviours. Candidate genes, related to suicide and …

COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis

H Chen, J Tu, P Ni, W Zhang, L Xu - Zhong nan da xue xue bao. Yi …, 2015 - europepmc.org
Objective To examine the relationship between COMT polymorphisms and the response to
antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic …

The role of COMT gene Val108/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis

TB González-Castro, Y Hernández-Díaz… - Neuropsychiatric …, 2018 - Taylor & Francis
Background It is accepted that there is a genetic factor that influences the risk of suicidal
behavior. The catechol-O-methyltransferase (COMT) gene, especially the Val108/158Met …

Polymorphisms of COMT Val158Met and DAT1 3′-UTR VNTR in Illicit Drug Use and Drug-Related Psychiatric Disorders

CK Chen, SK Lin, SC Chiang, LW Su… - Substance Use & …, 2014 - Taylor & Francis
To investigate the involvement of COMT Val158Met and DAT1 3′-UTR VNTR genotypes in
the pathogenesis of illicit drug use and drug-induced psychotic disorders (DIP), 187 …

No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders

G Zalsman, Y Huang, MA Oquendo… - Archives of suicide …, 2008 - Taylor & Francis
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism
(COMT-V158M) is associated with lower enzymatic activity than the Val allele and is …

COMT genotypes and use of antipsychotic medication: linking population‐based prescription database to the HUNT study

K Hagen, LJ Stovner, F Skorpen… - … and drug safety, 2008 - Wiley Online Library
Purpose The aim of this prospective study was to evaluate the impact of codon 158
polymorphism at the catechol‐O‐methyltransferase (COMT) gene on prescription of …

[PDF][PDF] The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results

L Hosak, J Libiger, L Cizek, M Beranek… - Neuroendocrinology …, 2006 - nel.edu
OBJECTIVES: Measurable traits of human personality may mark the predisposition to
psychopathology. Increased novelty seeking plays an important role in the pathogenesis of …