MRI brain shows bilaterally symmetrical, hyperintense signal changes in the anterior medial
globus pallidus, with surrounding hypointensity in the globus pallidus, on T2-weighted …

A9-YEAR-OLD BOY PRE-sented with worsen-ing dystonias and generalized stiffness of the
whole body for 2 months. He was the only child of a nonconsanguineous marriage, with …

BACKGROUND AND PURPOSE: A detailed delineation of the MR imaging changes in the
globus pallidus in pantothenate kinase–associated neurodegeneration will be helpful for …

THE “EYE-OF-THE-TIGER” signreferstoaspecific patternofhyperintensity within a
hypointense globus pallidus that is seen on T2-weighted magnetic resonance (MR) imaging …

Neurodegeneration with brain iron accumulation (NBIA, formerly known as Hallervorden-
Spatz syndrome) defines a group of genetic disorders characterized by brain iron …

We present a case of a 72-year-old man with a 9-year history of memory decline and 7-year
history of parkinsonian symptoms. An MRI demonstrated an “eye-of-the-tiger” sign in the …

Pantothenate kinase-associated neurodegeneration (PKAN)(MIM 234200; Hallervorden-
Spatz syndrome) is a degenerative, autosomal recessive disorder in childhood, currently …

Pantothenate kinase-associated neurodegeneration (PKAN) is an autosomal-recessive
disease characterized by iron accumulation in the brain due to PANK2 gene mutation. The …

Pantothenate kinase-associated neurodegeneration (PKAN) is a rare disorder associated
with brain iron accumulation caused by a recessive mutation in pantothenate kinase 2 gene …

Pantothenate kinase-associated neurodegeneration (PKAN), formerly known as
Hallervorden–Spatz syndrome (HSS), is an autosomal recessive neurodegenerative …