OBJECTIVE: Early myoclonic encephalopathy (EME) is a rare epileptic syndrome
characterized by neonatal onset of severe recurrent seizures of multiple types often resistant …

The aim of this study was to assess the effectiveness of topiramate (TPM) as an add-on
regimen in reducing seizure rate in a population sample of patients diagnosed with severe …

Background Topiramate is a broad-spectrum agent effective against primarily generalized
tonic-clonic seizures (PGTCS) as well as partial-onset seizures. Juvenile myoclonic epilepsy …

Purpose: This study was to evaluate the efficacy and safety of topiramate (TPM) in patients
with severe myoclonic epilepsy in infancy (SMEI) and refractory seizures. Methods: We …

BACKGROUND: Myoclonic-Astatic Epilepsy (MAE) usually starts before five years of age
and is associated with very frequent seizures and is highly resistant to treatment. AIM: To …

Objective The objective of this study is to describe the usefulness of topiramate in refractory
neonatal seizures. Results We reported the clinical off-label use of topiramate in three cases …

OBJECTIVE: Topiramate (TPM) is a new antiepileptic drug, which has a wide spectrum of
activities suggesting a potentially valuable therapeutic profile. Our objective is to report our …

To assess the efficacy, safety, and tolerability of topiramate in infants younger than 24
months of age, we conducted an open-label, multicenter chart review study of infants who …

Many studies showed that Topiramate (TPM) may be a useful drug in a wide spectrum of
childhood epilepsies. We report a 3-month-old female with stormy onset of secondarily …

OBJECTIVE: The aim of this study was to evaluate the efficacy and tolerability of topiramate
(TPM) in juvenile myoclonic epilepsy (JME). METHOD: We assessed seizure control and …