Definition of intractable epilepsy

S Sinha, KA Siddiqui - Neurosciences Journal, 2011 - nsj.org.sa
Defining intractable epilepsy is essential not only to identify up to 40% of patients refractory
to pharmacological management, but also to facilitate selection and comparison of such …

Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

P Kwan, A Arzimanoglou, AT Berg, MJ Brodie… - 2010 - Wiley Online Library
To improve patient care and facilitate clinical research, the International League Against
Epilepsy (ILAE) appointed a Task Force to formulate a consensus definition of drug resistant …

Interrater reliability of the international consensus definition of drug-resistant epilepsy: a pilot study

X Hao, ISM Wong, P Kwan - Epilepsy & Behavior, 2011 - Elsevier
We evaluated the interrater reliability of the consensus definition of drug-resistant epilepsy
proposed by the International League Against Epilepsy. According to the definition …

Antiepileptic drug therapy: when is epilepsy truly intractable?

PR Camfield, CS Camfield - Epilepsia, 1996 - Wiley Online Library
We define intractable in the first 5 years of epilepsy treatment as an average of at least one
seizure every 2 months. For the longer term, we define intractable as at least one seizure per …

Effect of dosage failed of first antiepileptic drug on subsequent outcome

MJ Brodie, SJE Barry, GA Bamagous, P Kwan - Epilepsia, 2013 - Wiley Online Library
Purpose: The recent definition of drug‐resistant epilepsy proposed by the International
League Against Epilepsy (ILAE) stipulated failure of an adequate trial of two tolerated …

Refractory epilepsy: clinical overview

JA French - Epilepsia, 2007 - Wiley Online Library
The incidence of refractory epilepsy remains high despite the influx of many new
antiepileptic drugs (AEDs) over the past 10 years. Epidemiological data indicate that 20 …

[CITATION][C] A graded system to categorize drug‐resistant epilepsy

J Gomez‐Alonso, A Gil‐Nagel - Epilepsia, 2010 - Wiley Online Library
Recently, a Task Force appointed by the International League Against Epilepsy (ILAE)
formulated a consensus definition of drug-resistant epilepsy as failure of two antiepileptic …

Towards a clinically meaningful definition of drug-resistance

A Arzimanoglou, P Ryvlin - Drug-Resistant Epilepsies, 2008 - books.google.com
Nearly 30% of patients with epilepsy are not controlled by currently available antiepileptic
drugs and/0r surgical procedures. Consequently, it is not surprising that terms like “drug …

The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in …

KS Wilcox, PJ West, CS Metcalf - Neuropharmacology, 2020 - Elsevier
Abstract The Epilepsy Therapy Screening Program (ETSP), formerly known as the
Anticonvulsant Screening Program (ASP), has played an important role in the preclinical …

Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug‐resistant focal epilepsy

M Mula, G Zaccara, CA Galimberti, B Ferrò… - …, 2019 - Wiley Online Library
Objective Although many studies have attempted to describe treatment outcomes in patients
with drug‐resistant epilepsy, results are often limited by the adoption of nonhomogeneous …