Infants and children are at a higher risk for seizures compared with adults. Increasing
experimental animal data strongly suggest young animals are less vulnerable than mature …

Temporal lobe epilepsy is a common form of epilepsy in human adults and is associated
with a unique pattern of damage in the hippocampus. The damage includes cell loss of the …

Purpose/aim of the study: Neonatal seizures are the most frequent type of neurological
disorder, and those newborn babies that experience seizures carry an increased risk of …

Prolonged early‐life seizures are considered potential risk factors for later epilepsy
development, but mediators of this process remain largely unknown. Seizure‐induced …

It is well documented that prolonged seizures (status epilepticus) can cause neuronal injury
and result in synaptic reorganization in certain brain regions. However, the effect of …

A Single Episode of Neonatal Seizures Permanently Alters Glutamatergic Synapses.
Cornejo BJ, Mesches MH, Coultrap S, Browning MD, Benke TA. Ann Neurol 2007; 61 (5) …

Do seizures cause neuronal death? At least in the immature hippocampus, this may not be
the critical question for determining the mechanisms of epileptogenesis. Neuronal injury and …

Recent evidence suggests that hippocampal damage can be both the result of seizure
activity and the cause of further chronic epilepsy. A review of current models of status …

Epilepsy is the third most common neurologic disorder and the one with the highest
incidence of seizures occurring early in life (41). In experimental epilepsy, a seizure results …

Both clinical and laboratory studies demonstrate that seizures early in life can result in
permanent behavioral abnormalities and enhance epileptogenicity. In experimental rodent …