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Research ArticleORIGINAL ARTICLES
Open Access

The ICAM-1 (469 T/C) gene polymorphism but not (241 G/A) is associated with Behcet’s disease in the Lebanese population

Hania N. Chmaisse, Hana A. Fakhoury, Nuha N. Salti and Rajaa F. Makki
Neurosciences Journal July 2006, 11 (3) 187-190;
Hania N. Chmaisse
Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, PO Box 115020, Beirut, Lebanon.
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Hana A. Fakhoury
Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, PO Box 115020, Beirut, Lebanon.
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Nuha N. Salti
Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, PO Box 115020, Beirut, Lebanon.
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Rajaa F. Makki
Department of Pharmacology, Faculty of Pharmacy, Beirut Arab University, PO Box 115020, Beirut, Lebanon.
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Abstract

OBJECTIVE: To investigate the association of the 2 intracellular adhesion molecules-1 (ICAM-1) gene polymorphisms [thymidine/cytidine (T/C) 469 and guanosine/adenosine (G/A) 241] in Behcet’s disease in Lebanon.

METHODS: We initiated the study in July 2003, and carried out the work in the research laboratory of Beirut Arab University, Beirut, Lebanon. We extracted the DNA by glass fiber matrix mini column. We amplified the ICAM gene by polymerase chain reaction (PCR) and tested the PCR products for the presence of the polymorphisms using a restriction enzyme specific for each polymorphism. We analyzed the results by agarose electrophoresis.

RESULTS: We demonstrated the association of only one single nucleotide polymorphism (SNP) (K469) with Behcet’s disease, while we could not detect the other SNP (G241A) in either controls or patients in the Lebanese population.

CONCLUSION: The ICAM-1 gene polymorphism 469 T/C, but not 241 G/A, may encode risk for Behcet’s disease in the Lebanese population.

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Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 11 (3)
Neurosciences Journal
Vol. 11, Issue 3
1 Jul 2006
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The ICAM-1 (469 T/C) gene polymorphism but not (241 G/A) is associated with Behcet’s disease in the Lebanese population
Hania N. Chmaisse, Hana A. Fakhoury, Nuha N. Salti, Rajaa F. Makki
Neurosciences Journal Jul 2006, 11 (3) 187-190;

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The ICAM-1 (469 T/C) gene polymorphism but not (241 G/A) is associated with Behcet’s disease in the Lebanese population
Hania N. Chmaisse, Hana A. Fakhoury, Nuha N. Salti, Rajaa F. Makki
Neurosciences Journal Jul 2006, 11 (3) 187-190;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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