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Research ArticleORIGINAL ARTICLES
Open Access

Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis

Sukru Caglar, Fuat Torun, Esra Erdemli and Ayse N. Torun
Neurosciences Journal April 2007, 12 (2) 114-119;
Sukru Caglar
Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
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Fuat Torun
Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
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Esra Erdemli
Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
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Ayse N. Torun
Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
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Abstract

OBJECTIVE: To investigate whether iloprost, a stable analog of prostacyclin, is useful for the preservation of neural grafts in transplantation surgery.

METHODS: This study was conducted at the Microsurgery Laboratory of the Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey in 2003. The animals (rabbits) were divided into 3 groups. In group I, autografts taken from the adrenal medulla were stored in 0.9% sodium chloride (NaCl) solution for 45 minutes before transplantation. In group II, autografts taken from the adrenal medulla were stored in iloprost solution (50 ng/ml) for 45 minutes before transplantation. Graft transplantation was not performed in the third group.

RESULTS: In group I, the grafts partially preserved their viability. In group II, the large adrenal medullary cells had evident euchromatin nuclei fused with neurons, and there was an increase in vascularization.

CONCLUSION: Three weeks after transplantation surgery, it was determined that iloprost maintained the viability of the graft tissue and probably prevented apoptosis, and facilitated the integration of the graft tissue into the host brain.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 12 (2)
Neurosciences Journal
Vol. 12, Issue 2
1 Apr 2007
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Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis
Sukru Caglar, Fuat Torun, Esra Erdemli, Ayse N. Torun
Neurosciences Journal Apr 2007, 12 (2) 114-119;

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Effect of iloprost on adrenal medullary grafts in central nervous system transplantation and apoptosis
Sukru Caglar, Fuat Torun, Esra Erdemli, Ayse N. Torun
Neurosciences Journal Apr 2007, 12 (2) 114-119;
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© 2023 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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