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Research ArticleORIGINAL ARTICLES
Open Access

Bone loss and bone turnover in acute and chronic spinal cord injured patients

Nurdan Paker, Derya Bugdayci, Sedef Ersoy, Elif Uysal and Sule Elbirlik
Neurosciences Journal July 2007, 12 (3) 232-235;
Nurdan Paker
Department of Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Bina ishani, No. 73/4 Nisantasi, Istanbul, Turkey. Tel. +90 (212) 2461538. Fax. +90 (212) 2465698. E-mail: [email protected]
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Derya Bugdayci
Department of Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Bina ishani, No. 73/4 Nisantasi, Istanbul, Turkey. Tel. +90 (212) 2461538. Fax. +90 (212) 2465698. E-mail: [email protected]
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Sedef Ersoy
Department of Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Bina ishani, No. 73/4 Nisantasi, Istanbul, Turkey. Tel. +90 (212) 2461538. Fax. +90 (212) 2465698. E-mail: [email protected]
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Elif Uysal
Department of Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Bina ishani, No. 73/4 Nisantasi, Istanbul, Turkey. Tel. +90 (212) 2461538. Fax. +90 (212) 2465698. E-mail: [email protected]
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Sule Elbirlik
Department of Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Bina ishani, No. 73/4 Nisantasi, Istanbul, Turkey. Tel. +90 (212) 2461538. Fax. +90 (212) 2465698. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate bone loss and the rate of bone turnover in individuals with spinal cord injury (SCI), and to compare the results with those healthy controls.

METHODS: This cross-sectional, controlled study was performed between January and December 2005, in the Istanbul Physical Medicine and Rehabilitation Training Hospital, Istanbul, Turkey. Forty-eight patients with SCI were included in the study. The control group consisted of 47 age and sex matched healthy subjects. Bone density was measured at the proximal hip region by dual-energy X-ray absorptiometry. Serum levels of osteocalcin (OC) and C telopeptide of type 1 collagen (CTX) were measured.

RESULTS: Femur neck and femur total bone mineral density values in the SCI patients and control group were 0.894 (0.188), 0.911 (0.185), and 0.994 (0.116), 1.063 (0.132) (p<0.03, p<0.000). Serum levels of OC and CTX were significantly increased in patients (p<0.015, p<0.000). Femur bone density in both neck and total regions showed a significant decrease in the SCI patients with longer injury duration (p<0.001, p<0.000). Serum CTX levels were markedly elevated in the first year of SCI. However, serum OC level showed no difference for the injury duration.

CONCLUSION: Significant bone loss was found at the proximal hip in SCI patients. Serum biochemical markers were also significantly higher in the patient group than the healthy controls. The bone density was lower in the long-standing SCI patients, although serum CTX levels were higher in the first 12 months after injury.

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Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 12 (3)
Neurosciences Journal
Vol. 12, Issue 3
1 Jul 2007
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Bone loss and bone turnover in acute and chronic spinal cord injured patients
Nurdan Paker, Derya Bugdayci, Sedef Ersoy, Elif Uysal, Sule Elbirlik
Neurosciences Journal Jul 2007, 12 (3) 232-235;

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Bone loss and bone turnover in acute and chronic spinal cord injured patients
Nurdan Paker, Derya Bugdayci, Sedef Ersoy, Elif Uysal, Sule Elbirlik
Neurosciences Journal Jul 2007, 12 (3) 232-235;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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