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Research ArticleORIGINAL ARTICLES
Open Access

Study on serum homocysteine level in Alzheimers disease and its relationship with the stages of this disease

Mahnaz Talebi, Mehdi Farhodi, Masood Nikanfar, Jafar Majidi and Ali Fakhari
Neurosciences Journal October 2008, 13 (4) 359-362;
Mahnaz Talebi
Department of Neurology, Neurological Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Tel/Fax. +98 (411) 3342889. E-mail: [email protected]
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Mehdi Farhodi
Department of Neurology, Neurological Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Tel/Fax. +98 (411) 3342889. E-mail: [email protected]
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Masood Nikanfar
Department of Neurology, Neurological Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Tel/Fax. +98 (411) 3342889. E-mail: [email protected]
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Jafar Majidi
Department of Neurology, Neurological Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Tel/Fax. +98 (411) 3342889. E-mail: [email protected]
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Ali Fakhari
Department of Neurology, Neurological Sciences Research Team, Imam Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. Tel/Fax. +98 (411) 3342889. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate homocysteine levels in Alzheimer’s disease and its relationship with the severity of disease.

METHODS: This investigation was performed as a case-control study on 40 Alzheimer patients and 40 non-Alzheimer patients in Tabriz, Iran from May 2006 to September 2007. Alzheimer patients were selected based on the criteria of the American Psychological Association. The severity of illness was determined based on Reisberg scale. Mental status of the patients was evaluated by Mini Mental State Examination (MMSE). The serum levels of homocysteine were measured by enzyme-linked immunosorbent assay method.

RESULTS: The average serum homocysteine level in the 40 patient group was 23.01+/-14.40mmol/L, and in the 40 patient control group was 15.40+/-6.23 (p=0.003). The average serum homocysteine level in the first group of patients was 21.7+/-12.7mmol/L, in the second group 22.3+/-13.8, and in the third group 24.9 +/- 17.2. The relationship between MMSE score and serum homocysteine level of patients was not significant (p=0.4).

CONCLUSION: The average serum homocysteine level in Alzheimer patients was higher than in the control group, however, it did not show a significant relationship with the severity of illness.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 13 (4)
Neurosciences Journal
Vol. 13, Issue 4
1 Oct 2008
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Study on serum homocysteine level in Alzheimers disease and its relationship with the stages of this disease
Mahnaz Talebi, Mehdi Farhodi, Masood Nikanfar, Jafar Majidi, Ali Fakhari
Neurosciences Journal Oct 2008, 13 (4) 359-362;

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Study on serum homocysteine level in Alzheimers disease and its relationship with the stages of this disease
Mahnaz Talebi, Mehdi Farhodi, Masood Nikanfar, Jafar Majidi, Ali Fakhari
Neurosciences Journal Oct 2008, 13 (4) 359-362;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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