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Research ArticleORIGINAL ARTICLES
Open Access

Topiramate as a long-term therapy in children with refractory epilepsy

Aycan Unalp, Nedret Uran, Tulin Hizli and Aysel Ozturk
Neurosciences Journal October 2008, 13 (4) 391-394;
Aycan Unalp
Department of Pediatric Neurology, Behcet Uz Child Diseases and Pediatric Surgery Training and Research Hospital, Izmir, Turkey. Tel. +90 (232) 2387097. Fax. +90 (232) 3668530. E-mail: [email protected]
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Nedret Uran
Department of Pediatric Neurology, Behcet Uz Child Diseases and Pediatric Surgery Training and Research Hospital, Izmir, Turkey. Tel. +90 (232) 2387097. Fax. +90 (232) 3668530. E-mail: [email protected]
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Tulin Hizli
Department of Pediatric Neurology, Behcet Uz Child Diseases and Pediatric Surgery Training and Research Hospital, Izmir, Turkey. Tel. +90 (232) 2387097. Fax. +90 (232) 3668530. E-mail: [email protected]
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Aysel Ozturk
Department of Pediatric Neurology, Behcet Uz Child Diseases and Pediatric Surgery Training and Research Hospital, Izmir, Turkey. Tel. +90 (232) 2387097. Fax. +90 (232) 3668530. E-mail: [email protected]
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Abstract

OBJECTIVE: To evaluate the long-term efficacy, safety, and retention rate of topiramate (TPM) in childhood refractory epilepsies.

METHODS: This study was designed as a single-center, retrospective study. Children with refractory epilepsy who has been followed in Behcet Uz Children’s Hospital, Izmir, Turkey, between 2003 and 2007 were included in the study.

RESULTS: The study population consisted of 43 boys (60.6%), and 28 girls (39.4%) aged between 2-18 years. Mean age was 8.83 (SD: 3.77) and mean duration of epilepsy was 3.89 (SD: 1.51) years. There were 41 children (57.7%) with mental retardation. Twenty-seven children had generalized epilepsy, and 44 children had localization-related epilepsy. Fifty-one children (71.8%) showed a good response to initial treatment. The retention at a mean of 32 months was 31 out of 71 children (43.6%), and approximately 18 children (25.3%) were seizure free. A loss of efficacy in long-term use occurred in 17 (33.3%) of initial responders. Adverse events were seen in 20 children (28.1%). There were no significant differences between the groups who continued and discontinued TPM treatment in long-term use.

CONCLUSION: As a result, it was determined that the drug was more effective and well tolerated in localization-related epilepsies, on long-term follow up.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 13 (4)
Neurosciences Journal
Vol. 13, Issue 4
1 Oct 2008
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Topiramate as a long-term therapy in children with refractory epilepsy
Aycan Unalp, Nedret Uran, Tulin Hizli, Aysel Ozturk
Neurosciences Journal Oct 2008, 13 (4) 391-394;

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Topiramate as a long-term therapy in children with refractory epilepsy
Aycan Unalp, Nedret Uran, Tulin Hizli, Aysel Ozturk
Neurosciences Journal Oct 2008, 13 (4) 391-394;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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