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Research ArticleORIGINAL ARTICLES
Open Access

Pattern of childhood neuronal migrational disorders in Oman

Roshan L. Koul, Amna M. Alfuitasi, Dilip K. Sankhla, Hashim Javad and Ranjan R. William
Neurosciences Journal April 2009, 14 (2) 158-162;
Roshan L. Koul
Department of Child Health, Sultan Qaboos University Hospital, PO Box 38, BW-1, Muscat 123, Sultanate of Oman. Fax. +968 24413128. E-mail: [email protected] / [email protected]
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Amna M. Alfuitasi
Department of Child Health, Sultan Qaboos University Hospital, PO Box 38, BW-1, Muscat 123, Sultanate of Oman. Fax. +968 24413128. E-mail: [email protected] / [email protected]
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Dilip K. Sankhla
Department of Child Health, Sultan Qaboos University Hospital, PO Box 38, BW-1, Muscat 123, Sultanate of Oman. Fax. +968 24413128. E-mail: [email protected] / [email protected]
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Hashim Javad
Department of Child Health, Sultan Qaboos University Hospital, PO Box 38, BW-1, Muscat 123, Sultanate of Oman. Fax. +968 24413128. E-mail: [email protected] / [email protected]
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Ranjan R. William
Department of Child Health, Sultan Qaboos University Hospital, PO Box 38, BW-1, Muscat 123, Sultanate of Oman. Fax. +968 24413128. E-mail: [email protected] / [email protected]
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Abstract

OBJECTIVE: To record the pattern of different neuronal migrational disorders (NMD) and their associated neurological conditions.

METHODS: The data were collected at the Child Neurology Services of Sultan Qaboos University Hospital, Oman, from January 1993 to September 2006 from all children with psychomotor delay and epilepsy, who underwent brain imaging (mostly MRI). The MR imaging was used for the diagnosis of a neuronal migration anomaly.

RESULTS: There were 86 cases of NMD. Corpus callosum agenesis and lissencephaly/pachygyria formed the major group. There were 48 cases of corpus callosum agenesis, and 16 cases of lissencephaly/pachygyria. Other disorders were 10 cases of heterotopias, 5 schizencephaly, 3 holoprosencephaly, 2 polymicrogyria, and one each of hemimegalencephaly, and hydranencephaly. Developmental delay was the most common associated finding noted in 80 (93%) cases. Sixty-seven (77.9%) cases had motor deficit. Forty out of 86 (46.5%) cases had epilepsy. Partial/partial complex seizures were the most common at 13 out of 40 (32.5%). Syndromic seizures were seen in 11 out of 40 (27.5%) cases. The seizures were controlled in only 3/40 (7.5%) cases.

CONCLUSION: The NMD constitute a significant number of child neurology patients with psychomotor delay and intractable epilepsy. Exogenic and genetic factors affecting the early embryonic and fetal development from sixth to twenty-sixth weeks of gestation result in NMD. Recent genetic studies are defining the underlying mechanism and these studies will help in early diagnosis and possible prevention of NMD.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 14 (2)
Neurosciences Journal
Vol. 14, Issue 2
1 Apr 2009
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Pattern of childhood neuronal migrational disorders in Oman
Roshan L. Koul, Amna M. Alfuitasi, Dilip K. Sankhla, Hashim Javad, Ranjan R. William
Neurosciences Journal Apr 2009, 14 (2) 158-162;

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Pattern of childhood neuronal migrational disorders in Oman
Roshan L. Koul, Amna M. Alfuitasi, Dilip K. Sankhla, Hashim Javad, Ranjan R. William
Neurosciences Journal Apr 2009, 14 (2) 158-162;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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