Article Figures & Data
Figures
- Figure 1
Terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining of apoptotic cells. Two weeks following induction of a facial nerve lesion, brain sections of the pontomedullary sulcus region obtained from different groups of animals were stained with TUNEL. Healthy brain tissue was used as a control. Representative figures of group A (A), group B (B), group C (C), and group D (D) are shown. TUNEL staining × 400. Apoptotic cells are indicated by arrows.
Tables
- Table 1
Number of apoptotic cells at indicated time following induction of a facial nerve lesion.
Groups Day 0 Day 7 Day 14 Day 28 Day 42 A 2.16 ± 1.32 — — — — B — 18.40 ± 1.43 26.20 ± 1.75 13.10 ± 1.20 9.30 ± 0.67 C — 11.00 ± 1.25*† 15.60 ± 0.97*† 7.20 ± 1.03*† 4.60 ± 0.84*† D — 13.70 ± 1.06* 20.30 ± 0.82* 8.50 ± 1.27* 5.70 ± 1.16* - Table 2
Effects of nerve growth factor on caspase-3 expression in injured facial nerve at indicated times following induction of facial nerve lesion.
Groups Day 0 Day 7 Day 14 Day 28 Day 42 A 15.90 ± 2.33 — — — — B — 84.70 ± 3.47 118.20 ± 3.65 60.40 ± 5.23 40.30 ± 5.74 C — 53.8 ± 5.07*† 78.30 ± 4.22*† 26.90 ± 4.18*† 20.0 ± 3.83*† D — 64.10 ± 3.38* 96.40 ± 6.59* 38.50 ± 3.92* 27.20 ± 4.44* ↵* p<0.01 compared with group B (day 7, p=0.000, day 14, p=0.000, day 28, p=0.000, day 42, p=0.000),
↵† p<0.01 compared with group D (day 7, p=0.000, day 14, p=0.000, day 28, p=0.000, day 42, p=0.002). A - healthy controls, B - facial nerve lesion model + normal saline injection, C facial nerve lesion model + NGF injection through the stylomastoid foramen, D facial nerve lesion model + intraperitoneal injection of NGF
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