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Research ArticleOriginal Articles
Open Access

The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey

Gulistan Halac, Gulsen M. Sezer, Neslihan O. Saglam, Pinar Tekturk, Aysegul D. Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı and Talip Asil
Neurosciences Journal October 2015, 20 (4) 336-340; DOI: https://doi.org/10.17712/nsj.2015.4.20150268
Gulistan Halac
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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  • For correspondence: [email protected]
Gulsen M. Sezer
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Neslihan O. Saglam
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Pinar Tekturk
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Aysegul D. Demir
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Saliha Demir
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Faruk Akcay
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Aysegul Uslu
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Zuhal Yapıcı
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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Talip Asil
From the Departments of Neurology (Halac, Asil), Pediatry (Demir A), Physical Medicine and Rehabilitation (Demir S), Medical Faculty, Bezmialem Vakıf University, and the Department of Pediatry (Sezer, Akcay, Uslu), Kagıthane State Hospital, and the Department of Pediatry (Saglam), Bakırköy Dr. Sadi Konuk Educational and Research Hospital, and from the Division of Child Neurology (Tekturk, Yapıcı), Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
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    Table 1

    Demographic and clinical characteristics of Turkish pediatric patients with and without anemia.

    VariablesPatients with anemiaPatients without anemiaP-value
    Number of patients98102
    Age (years) (mean±SD)15.4±1.911.5±2.50.000
    Gender (female/male) (n)88/1051/510.000
    Ferritin, µg/ml (mean±SD)6.01±3.436.9±19.40.000
    Presence of RLS n (%)60 (61.2)38 (37.3)0.001
    SD - standard deviation, n - number of patients, RLS - Restless Leg Syndrome
    • View popup
    Table 2

    Presence of RLS in Turkish pediatric patients with ferritin levels above and below 50 ng/dl.

    VariablesPresence of RLS/WEDAbsence of RLS/WEDTotalP-value
    n (%)
    Patients with ferritin levels more than 50ng/mL2 (7.7)24 (92.3)26 (11.6)0.000
    Patients with ferritin levels less than 50ng/mL96 (55.2)78 (44.8)174 (89.4)
    RLS - Restless Leg Syndrome, WED - Willis-Ekbom Disease
    • View popup
    Table 3

    Multivariate logistic regression analysis of potential risk factors for presence of RLS among Turkish pediatric patients.

    VariableOR95% CIP-value
    Age (years)0.980.87-1.10.78
    Gender0.850.39-1.820.68
    Ferritin (ng/ml)0.950.93-0.970.000
    OR - odds ratio, CI - confidence interval, RLS - Restless Leg Syndrome
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Neurosciences Journal: 20 (4)
Neurosciences Journal
Vol. 20, Issue 4
1 Oct 2015
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The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
Gulistan Halac, Gulsen M. Sezer, Neslihan O. Saglam, Pinar Tekturk, Aysegul D. Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı, Talip Asil
Neurosciences Journal Oct 2015, 20 (4) 336-340; DOI: 10.17712/nsj.2015.4.20150268

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The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
Gulistan Halac, Gulsen M. Sezer, Neslihan O. Saglam, Pinar Tekturk, Aysegul D. Demir, Saliha Demir, Faruk Akcay, Aysegul Uslu, Zuhal Yapıcı, Talip Asil
Neurosciences Journal Oct 2015, 20 (4) 336-340; DOI: 10.17712/nsj.2015.4.20150268
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