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Brief ReportBrief Communication
Open Access

Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan

Abla Albsoul-Younes, Lubna Gharaibeh, Amer A. Murtaja, Amira Masri, Ibrahim Alabbadi and Abdelkarim A. Al-Qudah
Neurosciences Journal July 2016, 21 (3) 264-267; DOI: https://doi.org/10.17712/nsj.2016.3.20150766
Abla Albsoul-Younes
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
BSc, PhD
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  • For correspondence: [email protected] [email protected]
Lubna Gharaibeh
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
BSc, MSc
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Amer A. Murtaja
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
BSc, MSc
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Amira Masri
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
MD
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Ibrahim Alabbadi
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
BSc, PhD
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Abdelkarim A. Al-Qudah
From the Department of Biopharmaceutics and Clinical Pharmacy (Albsoul-Younes, Gharaibeh, Murtaja, Alabadi), Faculty of Pharmacy, Department of Pediatric (Masri, Al-Qudah), Faculty of Medicine, Hamdi Mango Center for Scientific Research (Albsoul-Younes), The University of Jordan, Amman, Jordan
MD
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Article Figures & Data

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    Table 1

    Participants’ characteristics. n= 694

    Variablesn (%)
    Gender
     Male388 (55.9)
     Female306 (44.1)
     Age, years, mean ± SD8.6±4.5
    Age groups
     <1 year28 (4.0)
     1 to <6 years229 (33.0)
     6 years to <12 years289 (41.6)
     12 years to 18 years148 (21.3)
    Distribution of patients by centers
     Educational478 (68.9)
     Governmental216 (31.1)
    • View popup
    Table 2

    Frequency of initial therapy in monotherapy and combination therapy in 696 patients.

    MonotherapyCombination therapy
    Antiepileptic drug usedn (%)Antiepileptic drug usedn (%)
    Valproic acid329 (47.4)Lamotrigine17 (2.4)
    Carbamazepine209 (30.1)Oxcarbazepine5 (0.7)
    Phenobarbitone50 (7.2)Vigabatrin4 (0.6)
    Levetiracetam30 (4.3)Gabapentin1 (0.1)
    Topiramate29 (4.2)Phenytoin1 (0.1)
    Clonazepam18 (2.6)Vitamin B61 (0.1)
    • View popup
    Table 3

    Frequency of antiepileptic monotherapy and dual combinations.

    Monotherapy n= 465n (%)Dual therapy combinations n=162n (%)
    Valproic acid235 (50.5)Valproic acid+Carbamazepine28 (17.3)
    Carbamazepine155 (33.3)Carbamazepine+Levetiracetam21 (13)
    Levetiracetam19 (4.1)Valproic acid+Levetiracetam20 (12.3)
    Phenobarbitone17 (3.7)Valproic acid+Topiramate16 (9.9)
    Topiramate16 (3.4)Valproic acid+Phenobarbitone12 (7.4)
    Lamotrigine12 (2.6)Valproic acid+Clonazepam12 (7.4)
    Oxcarbazepine5 (1.1)Valproic acid+Lamotrigine9 (5.6)
    Others11 (1.3)Others44 (27.1)
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Neurosciences Journal: 21 (3)
Neurosciences Journal
Vol. 21, Issue 3
1 Jul 2016
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Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan
Abla Albsoul-Younes, Lubna Gharaibeh, Amer A. Murtaja, Amira Masri, Ibrahim Alabbadi, Abdelkarim A. Al-Qudah
Neurosciences Journal Jul 2016, 21 (3) 264-267; DOI: 10.17712/nsj.2016.3.20150766

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Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan
Abla Albsoul-Younes, Lubna Gharaibeh, Amer A. Murtaja, Amira Masri, Ibrahim Alabbadi, Abdelkarim A. Al-Qudah
Neurosciences Journal Jul 2016, 21 (3) 264-267; DOI: 10.17712/nsj.2016.3.20150766
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