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Open Access

The non-syndromic clinical spectrums of mtDNA 3243A>G mutation

Xiya Shen and Ailian Du
Neurosciences Journal April 2021, 26 (2) 128-133; DOI: https://doi.org/10.17712/nsj.2021.2.20200145
Xiya Shen
From the Department of Neurology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
MD
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Ailian Du
From the Department of Neurology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
MD, PhD
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    Table 1

    - Clinical phenotypes due to m.3243A>G mutation in the tRNALeu gene (UUR).

    Syndromic phenotypesNon-syndromic symptoms
    Neurological disordersMELAS, LS, MELAS/LS, KSS, CPEO, MERRF, NARP,Migraine, cerebella ataxia, seizures, autism, depression, anxiety, mental retardation, tension-type cluster headaches, polyneuropathy, myelopathy, calcification of basal ganglia
    Muscle disordersCPEO, MERRFexercise intolerance, muscle atrophy, myalgia, muscle cramp, hypercreatine kinase Hypertrophic cardiomyopathy, dilated cardiomyopathy, conduction
    Cardiovascular disordersSADS, WPW syndrome,block, ventricular extrasystoles, supraventricular tachycardia, atrial fibrillation, regurgitation of various valves
    Endocrine disordersMIDDDiabetes, growth hormone deficiency, hyperparathyroidism, hypoparathyroidism hypogonadism, hypothyroidism
    Ocular impairmentNARP, CPEOPigmentary retinopathy, cortical blindness, visual field defect, night blindness, cataract, macular dystrophy and optic atrophy
    Otolaryngologic impairmentMIDDsensorineural hearing loss; bilateral vestibular loss
    Digestive systemIPOVomiting, diarrhea, constipation, acute pancreatitis, celiac disease
    Kidney impairmentnonerenal failure, nephropathy, maternal hereditary recurrent kidney stone, renal tubular acidosis
    Pregnancy and deliverynoneMiscarriage, gestational diabetes, premature delivery, intrauterine growth retardation, preeclampsia, cesarean section
    Othersnoneshort statures, stuttering, hypertriglyceridaemia, hair loss, Hypertrichosis, Dark complexion

    MELAS - mitochondrial encephalomyopathy, lactic acidosis, stroke-like attack; LS - Leigh syndrome; KSS - Keams- Sayre syndrome; CPEO - chronic progressive external ophthalmoplegia; NARP - neurogenic weakness, ataxia, and retinitis pigmentosa; MERRF - myoclonic epilepsy and ragged-red fiber disease; SADS - sudden adult death syndrome; WPW - Wolff-Parkinson-White syndrome; MIDD - Maternally Inherited Diabetes and Deafness; IPO - Intestinal pseudo-obstruction

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    Neurosciences Journal: 26 (2)
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    1 Apr 2021
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    The non-syndromic clinical spectrums of mtDNA 3243A>G mutation
    Xiya Shen, Ailian Du
    Neurosciences Journal Apr 2021, 26 (2) 128-133; DOI: 10.17712/nsj.2021.2.20200145

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    The non-syndromic clinical spectrums of mtDNA 3243A>G mutation
    Xiya Shen, Ailian Du
    Neurosciences Journal Apr 2021, 26 (2) 128-133; DOI: 10.17712/nsj.2021.2.20200145
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