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Research ArticleORIGINAL ARTICLES
Open Access

Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits

Mehmet Gurbilek, Cemile Topcu, Mehmet AkOz, Hulagu Bariskaner, Mehmet E. Ustun and Oznur KOylu
Neurosciences Journal April 2006, 11 (2) 88-92;
Mehmet Gurbilek
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Cemile Topcu
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Mehmet AkOz
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Hulagu Bariskaner
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Mehmet E. Ustun
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Oznur KOylu
Department of Biochemistry, Selcuk University Meram School of Medicine, Meram Konya, Turkey. Tel. +90 (332) 2237120. Fax. +90 (332) 3232641. E-mail: [email protected]
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Abstract

OBJECTIVE: To study the effects of deferoxamine on tissue sodium-potassium adenosine triphosphatase (Na+-K+ ATPase) activity on cerebral ischemia in rabbits.

METHODS: We cared for the animals in the Pharmacology Department of the Medical School of Selcuk University in 2004. We used 30, New Zealand, 7-day-old male rabbits in the experiment. We anesthetized all the animals with xylazine hydrochloric acid and ketamine. We divided the rabbits equally into 3 groups. In group 1 (n=10) (sham group), we observed baseline levels, and did not apply ischemia. In group 2 (n=10) (untreated group) we produced cerebral ischemia by clamping the bilateral common carotid arteries for 60 minutes, and in group 3 (n=10), we administered deferoxamine (DFO) 50 mg/kg intravenously immediately after opening the clamps.

RESULTS: The Na+-K+ATPase activity increased after DFO treatment (p=0.045).

CONCLUSION: We conclude that Na+-K+ATPase activity in cortical brain tissue was higher in DFO-treated rabbits compared with untreated animals after ischemia.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 11 (2)
Neurosciences Journal
Vol. 11, Issue 2
1 Apr 2006
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Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits
Mehmet Gurbilek, Cemile Topcu, Mehmet AkOz, Hulagu Bariskaner, Mehmet E. Ustun, Oznur KOylu
Neurosciences Journal Apr 2006, 11 (2) 88-92;

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Effect of deferoxamine on Na+K+ATPase activity after cerebral ischemia in rabbits
Mehmet Gurbilek, Cemile Topcu, Mehmet AkOz, Hulagu Bariskaner, Mehmet E. Ustun, Oznur KOylu
Neurosciences Journal Apr 2006, 11 (2) 88-92;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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