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Research ArticleORIGINAL ARTICLES
Open Access

Detection of rifampin resistant tuberculosis meningitis by polymerase chain reaction linked single strand conformation polymorphism analysis of cerebrospinal fluid

Kiarash Ghazvini, Ashraf T. Sani, Sara Rastegari, Javad Ghanaat and Mahdi Behdani
Neurosciences Journal April 2007, 12 (2) 105-108;
Kiarash Ghazvini
Department of Microbiology and Virology, Mashhad University of Medical Science, Mashhad, Iran. Tel. +98 (511) 8012562 / 6092547. E-mail: [email protected]
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Ashraf T. Sani
Department of Microbiology and Virology, Mashhad University of Medical Science, Mashhad, Iran. Tel. +98 (511) 8012562 / 6092547. E-mail: [email protected]
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Sara Rastegari
Department of Microbiology and Virology, Mashhad University of Medical Science, Mashhad, Iran. Tel. +98 (511) 8012562 / 6092547. E-mail: [email protected]
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Javad Ghanaat
Department of Microbiology and Virology, Mashhad University of Medical Science, Mashhad, Iran. Tel. +98 (511) 8012562 / 6092547. E-mail: [email protected]
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Mahdi Behdani
Department of Microbiology and Virology, Mashhad University of Medical Science, Mashhad, Iran. Tel. +98 (511) 8012562 / 6092547. E-mail: [email protected]
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Abstract

OBJECTIVE: To rapidly detect rifampin resistance in Mycobacterium tuberculosis isolates causing meningitis in northeast Iran.

METHODS: This study presents the results of a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis for the evaluation of rifampin resistance directly from the CSF of 47 patients strongly suspicious to have tuberculosis meningitis in Emam Reza University Hospital, Mashhad, Iran over 3 years (2002 to 2005). Each CSF sample underwent microscopic examination, culture and DNA amplification by 2 PCR protocols and subsequent detection of mutations by SSCP analysis.

RESULTS: Among these patients, no mutations were revealed in the rpoB segment by SSCP.

CONCLUSION: The SSCP analyses of these samples shows complete susceptibility to rifampin. The use of this method can radically reduce the time needed to provide clinicians with data useful in aiding the selection of appropriate drugs.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 12 (2)
Neurosciences Journal
Vol. 12, Issue 2
1 Apr 2007
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Detection of rifampin resistant tuberculosis meningitis by polymerase chain reaction linked single strand conformation polymorphism analysis of cerebrospinal fluid
Kiarash Ghazvini, Ashraf T. Sani, Sara Rastegari, Javad Ghanaat, Mahdi Behdani
Neurosciences Journal Apr 2007, 12 (2) 105-108;

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Detection of rifampin resistant tuberculosis meningitis by polymerase chain reaction linked single strand conformation polymorphism analysis of cerebrospinal fluid
Kiarash Ghazvini, Ashraf T. Sani, Sara Rastegari, Javad Ghanaat, Mahdi Behdani
Neurosciences Journal Apr 2007, 12 (2) 105-108;
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© 2023 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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