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Case ReportCASE REPORTS
Open Access

Tiagabine-induced non-convulsive status epilepticus in a patient without history of epilepsy

Naim I. Haddad, Gopalan Umashankar and Sami I. Harik
Neurosciences Journal April 2007, 12 (2) 152-154;
Naim I. Haddad
Department of Neurology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 500, Little Rock, AR 72205, United States of America. Tel. +1 (501) 6865135. Fax. +1 (501) 6868689. E-mail: [email protected]
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Gopalan Umashankar
Department of Neurology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 500, Little Rock, AR 72205, United States of America. Tel. +1 (501) 6865135. Fax. +1 (501) 6868689. E-mail: [email protected]
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Sami I. Harik
Department of Neurology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Slot 500, Little Rock, AR 72205, United States of America. Tel. +1 (501) 6865135. Fax. +1 (501) 6868689. E-mail: [email protected]
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Abstract

Cases of non-convulsive status epilepticus (NCSE) induced by tiagabine (TGB) were occasionally reported. Almost all had a prior history of epilepsy. We describe here, the clinical and EEG findings in a patient, without history of seizures, who after the start of TGB developed NCSE. A 53-year-old man with history of paranoid schizophrenia, presented with “alteration of his mental state.” Three weeks early, TGB was added to his psychiatric regimen. On the second day of admission, he became unresponsive with a blank stare. Concomitant EEG showed abundant sharp and slow wave complexes. The episode lasted for 4 hours and was aborted by the intravenous administration of lorazepam. The TGB was discontinued without recurrence of subsequent seizure activity. This case supports the contention that TGB can induce NCSE in subjects not previously known to have seizures.

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Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 12 (2)
Neurosciences Journal
Vol. 12, Issue 2
1 Apr 2007
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Tiagabine-induced non-convulsive status epilepticus in a patient without history of epilepsy
Naim I. Haddad, Gopalan Umashankar, Sami I. Harik
Neurosciences Journal Apr 2007, 12 (2) 152-154;

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Tiagabine-induced non-convulsive status epilepticus in a patient without history of epilepsy
Naim I. Haddad, Gopalan Umashankar, Sami I. Harik
Neurosciences Journal Apr 2007, 12 (2) 152-154;
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© 2023 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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