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Research ArticleORIGINAL ARTICLES
Open Access

Protective effect of omega-3 fatty acids in a rat focal cerebral ischemia-reperfusion model

Ahmet Kavakli, Evren Kose, Ilter Kus, Ismail Zararsiz, Nusret Akpolat and Mustafa Sarsilmaz
Neurosciences Journal July 2007, 12 (3) 198-201;
Ahmet Kavakli
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Evren Kose
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Ilter Kus
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Ismail Zararsiz
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Nusret Akpolat
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Mustafa Sarsilmaz
Department of Anatomy, School of Medicine, Firat University, 23119 Elazig, Turkey. Tel. +90 (424) 2370000. Ext. 4626. Fax. +90 (424) 2379138. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate possible neuroprotective effects of dietary supplementation of fish oil in brain ischemia-reperfusion (I/R).

METHODS: This investigation took place in the Experimental Research Unit, Firat University, Elazig, Turkey, from January-February 2006. The study was carried out on 12 male Wistar rats; divided into 2 groups: I/R (control) and I/R + omega-3 essential fatty acids (EFA) (experiment). The rats in the I/R group received only ordinary rat food before middle cerebral artery (MCA) occlusion. The I/R + omega-3 EFA group received omega-3 fatty acid daily via intragastric gavage (300 mg/kg Marincap capsule) with normal food before MCA occlusion for 30 days. Structural alterations in the brain tissues were semi-quantitatively analyzed (0: absent, +: slight, ++: moderate, +++: severe).

RESULTS: There was evident severe (+++) edema, vacuolization, and eosinophilic degeneration in the I/R group, while only slight (+) edema and eosinophilic degeneration in the I/R + omega-3 EFA group in which no vacuolization was determined. These findings are consistent with the available studies in this field.

CONCLUSION: Results from this study indicate the beneficial effects of omega-3 EFA supplementation in prevention of I/R - induced damage in rats.

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Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 12 (3)
Neurosciences Journal
Vol. 12, Issue 3
1 Jul 2007
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Protective effect of omega-3 fatty acids in a rat focal cerebral ischemia-reperfusion model
Ahmet Kavakli, Evren Kose, Ilter Kus, Ismail Zararsiz, Nusret Akpolat, Mustafa Sarsilmaz
Neurosciences Journal Jul 2007, 12 (3) 198-201;

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Protective effect of omega-3 fatty acids in a rat focal cerebral ischemia-reperfusion model
Ahmet Kavakli, Evren Kose, Ilter Kus, Ismail Zararsiz, Nusret Akpolat, Mustafa Sarsilmaz
Neurosciences Journal Jul 2007, 12 (3) 198-201;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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