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Research ArticleOriginal Article
Open Access

Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice

Fatma S. Kilic, Dilek Kulluk and Ahmet Musmul
Neurosciences Journal April 2014, 19 (2) 100-105;
Fatma S. Kilic
Department of Pharmacology, Medical Faculty, Eskisehir Osmangazi University, Meselik 26480, Eskisehir, Turkey. Tel. +90 (222) 2392979 Ext. 4564. Fax. +90 (222) 2393772. E-mail: [email protected]
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Dilek Kulluk
Department of Pharmacology, Medical Faculty, Eskisehir Osmangazi University, Meselik 26480, Eskisehir, Turkey. Tel. +90 (222) 2392979 Ext. 4564. Fax. +90 (222) 2393772. E-mail: [email protected]
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Ahmet Musmul
Department of Pharmacology, Medical Faculty, Eskisehir Osmangazi University, Meselik 26480, Eskisehir, Turkey. Tel. +90 (222) 2392979 Ext. 4564. Fax. +90 (222) 2393772. E-mail: [email protected]
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Abstract

OBJECTIVE: To examine the effects of dehydroepiandrosterone (DHEA) on animal models of schizophrenia.

METHODS: Seventy Swiss albino female mice (25-35 g) were divided into 4 groups: amphetamine-free (control), amphetamine, 50, and 100 mg/kg DHEA. The DHEA was administered intraperitoneally (ip) for 5 days. Amphetamine (3 mg/kg ip) induced hyper locomotion, apomorphine (1.5 mg/kg subcutaneously [sc]) induced climbing, and haloperidol (1.5 mg/kg sc) induced catalepsy tests were used as animal models of schizophrenia. The study was conducted at the Animal Experiment Laboratories, Department of Pharmacology, Medical School, Eskisehir Osmangazi University, Eskisehir, Turkey between March and May 2012. Statistical analysis was carried out using Kruskal-Wallis test for hyper locomotion, and one-way ANOVA for climbing and catalepsy tests.

RESULTS: In the amphetamine-induced locomotion test, there were significant increases in all movements compared with the amphetamine-free group. Both DHEA 50 mg/kg (p<0.05), and 100 mg/kg (p<0.01) significantly decreased all movements compared with the amphetamine-induced locomotion group. There was a significant difference between groups in the haloperidol-induced catalepsy test (p<0.05). There was no significant difference between groups in terms of total climbing time in the apomorphine-induced climbing test (p>0.05).

CONCLUSION: We observed that DHEA reduced locomotor activity and increased catalepsy at both doses, while it had no effect on climbing behavior. We suggest that DHEA displays typical neuroleptic-like effects, and may be used in the treatment of schizophrenia.

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Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 19 (2)
Neurosciences Journal
Vol. 19, Issue 2
1 Apr 2014
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Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice
Fatma S. Kilic, Dilek Kulluk, Ahmet Musmul
Neurosciences Journal Apr 2014, 19 (2) 100-105;

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Effects of dehydroepiandrosterone in amphetamine-induced schizophrenia models in mice
Fatma S. Kilic, Dilek Kulluk, Ahmet Musmul
Neurosciences Journal Apr 2014, 19 (2) 100-105;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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