Research ArticleOriginal Article
Open Access

Association between human leukocyte antigen-DR and demylinating Guillain-Barré syndrome

Zaki N. Hasan, Haider H. Zalzala, Hyam R. Mohammedsalih, Batool M. Mahdi, Laheeb A. Abid, Zena N. Shakir and Maithem J. Fadhel
Neurosciences Journal October 2014, 19 (4) 301-305;

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Tables

  • Table 1

    Human leukocyte antigen (HLA) class II DRB genotypes in Iraqi Arab patients with Guillain-Barré Syndrome in comparison with a healthy control group.

    HLA-allelesGuillain-Barré syndrome patients group (n=30)Healthy control group (n=42)Odds ratio (95% confidence interval)P-value
    n (%)
    DRB1*
     03:0114 (46.7)4 (9.5)8.312 (2.36-29.17)0.0009
     03:1705 (11.9)NANA
     03:422 (6.7)0NANA
     03:762 (6.7)0NANA
     04:014 (13.3)0NANA
     07:0112 (40.0)2 (4.8)13.33 (2.7-65.84)0.0015
     08:0102 (9.1)NANA
     11:014 (13.3)2 (4.8)-0.213
     11:022 (2.6)2 (4.8)-0.729
     11:0307 (16.7)NANA
     11:1192 (6.7)0NANA
     11:132 (6.7)0NANA
     11:6708 (19.0)NANA
     12:014 (13.3)0NANA
     12:0902 (4.8)NANA
     13:016 (20.0)2 (4.8)-0.44
     13:0503 (7.1)NANA
     13:11605 (11.9)NANA
     13:11908 (19.0)NANA
     13:1804 (9.5)NANA
     14:0102 (4.8)NANA
     14:0203 (7.1)NANA
     14:1603 (7.1)NANA
     14:5704 (9.5)NANA
     15:016 (20.0)0NANA
    DRB3*
     01:0124 (80.0)40 (95.0)-0.0602
    DRB4*
     01:0118 (60.0)2 (4.7)30.000 (6.07-148.14)0.0001
    DRB5*
     01:014 (13.3)0NANA
    • Table 2

      Major histocompatibility complex class II (human leukocyte antigen-DR) serotypes in Iraqi Arabic patients with Guillain-Barré syndrome in comparison with a healthy control group.

      Human leukocyte antigen serology alleleNo. of alleles in patients (n=30)No. of alleles in controls (n=42)Odds ratio (95% confidence ratio)P-value
      n (%)
      DR2 6 (20.0)0
      DR318 (60.0)9 (21.4)5.5 (1.9485-15.5249)0.0013
      DR44 (13.3)0N.ANA
      DR514 (46.7)19 (54.5)0.9054
      DR66 (20.0)32 (45.2)0.0806 (0.0257-0.2531)0.0001
      DR712 (40.0)2 (4.8)13.3333 (2.7001-65.8423)0.0015
      DR802 (4.8)NA
      DR900NA
      DR1000NA
    • Table 3

      Major histocompatibility complex class II (human leukocyte antigen [HLA]-DR) serotypes in Iraqi Arabic patients with Guillain-Barré syndrome (GBS) in comparison with a healthy control group.

      HLA allelesGBS patients with complications (n=12)GBS patients without complications (n=18)P-value
      n (%)
      DRB1*
       03:016 (50.0)8 (44.4)1.000
       03:4202 (11.1)NA
       03:7602 (11.1)NA
       04:012 (16.7)2 (11.1)1.000
       07:014 (33.3)8 (44.4)0.708
       11:012 (16.7)4 (33.3)1.000
       11:022 (16.7)0NA
       11:1192 (16.7)0NA
       11:1302 (11.1)NA
       12:0104 (33.3)NA
       13:016 (50.0)0NA
       15:012 (16.7)4 (33.3)NA
      DRB3*
       01:0110 (83.3)14 (77.8)1.000
      DRB4*
       01:016 (50.0)12 (66.7)0.458
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