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Research ArticleOriginal Article
Open Access

Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants

Mohamed A. Talat, Anwar Ahmed and Lamia Mohammed
Neurosciences Journal October 2015, 20 (4) 341-345; DOI: https://doi.org/10.17712/nsj.2015.4.20150336
Mohamed A. Talat
From the Department of Pediatrics (Talat, Ahmed), and the Department of Clinical Pathology (Mohammed), Faculty of Medicine, Zagazig University, Zagazig, Egypt
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  • For correspondence: [email protected]
Anwar Ahmed
From the Department of Pediatrics (Talat, Ahmed), and the Department of Clinical Pathology (Mohammed), Faculty of Medicine, Zagazig University, Zagazig, Egypt
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Lamia Mohammed
From the Department of Pediatrics (Talat, Ahmed), and the Department of Clinical Pathology (Mohammed), Faculty of Medicine, Zagazig University, Zagazig, Egypt
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Article Figures & Data

Tables

    • View popup
    Table 1

    Significant differences between the groups regarding laboratory findings of serum zinc and copper only N=90).

    Laboratory findingsCasesControlst-testP-value
    (mean± standard deviation)
    Copper180.1±32.4114.5±18.57.245<0.001**
    Zinc60.1±22.6102.1±186.262<0.001**
    Total bilirubin0.5±0.20.4±0.11.2120.232
    SGOT28.3±1229.1±110.070.789
    SGPT38.2±1037.4±120.080.78
    Albumin3.9±0.54±0.50.4310.668
    Total protein6.8±27.9±32.790.099
    Urea30.8±6.827.3±41.820.076
    Creatinine0.6±0.10.5±0.11.3480.06
    • SGOT - serum glutamic-oxaloacetic yransaminase, SGPT - serum glutamic-pyruvic transaminase,

    • ↵** p>0.05 were statistically significant

    • View popup
    Table 2

    Type of seizure, type of treatment, and response to treatment based on gender (N=90).

    ConvulsionGenderX2P-value
    Male n=63Female n=27
    n (%)
    Type of seizure
     Generalized45 (71.4)24 (88.9)1.070.3
     Partial18 (28.6)3 (11.1)
    Type of response to treatment
     Non responder12 (19.1)6 (22.2)0.040.979
     Moderate responder36 (57.1)15 (55.6)
     Complete responder15 (23.8)6 (22.2)
    Type of treatment
     Single drug18 (28.6)15 (55.6)1.980.159
     Multiple drugs45 (71.4)12 (44.4)
    • View popup
    Table 3

    Laboratory findings between patients groups based on response to treatment.

    Laboratory findingsResponse to treatmentFP-value
    Non responderModerate responderComplete responder
    (mean± standard deviation)
    Copper167.2±31175±26.7184.7±24.40.6030.561
    Zinc73.8±33.457±24.358.2±8.20.8630.443
    Total bilirubin0.4±0.20.5±0.10.4±0.20.5050.614
    SGOT28±7.229±6.928.2±8.90.0250.975
    SGPT35.5±5.638.6±5.439.8±5.60.9680.404
    Albumin3.8±0.43.9±0.54.2±0.60.6990.514
    Total protein6.7±0.26.9±0.46.7±0.20.8250.601
    Urea30.3±5.532.8±5.87.7±3.10.1980.822
    Creatinine0.6±0.20.6±0.10.5±0.10.3450.714
    SGOT - serum glutamic-oxaloacetic yransaminase,
    SGPT - serum glutamic-pyruvic transaminase
    • View popup
    Table 4

    Serum levels of zinc and copper based on single drug usage.

    Serum levelSodium valporate n=27Carbamazepine n=12T-testP-value
    Mean±SD
    Serum Zinc65±0.0552±8.15.580.024
    Serum Copper144.7±8195±119.470.004
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Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants
Mohamed A. Talat, Anwar Ahmed, Lamia Mohammed
Neurosciences Journal Oct 2015, 20 (4) 341-345; DOI: 10.17712/nsj.2015.4.20150336

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Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants
Mohamed A. Talat, Anwar Ahmed, Lamia Mohammed
Neurosciences Journal Oct 2015, 20 (4) 341-345; DOI: 10.17712/nsj.2015.4.20150336
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