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Research ArticleOriginal Article
Open Access

Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression

Vildan Binay Safer, Sibel Ozbudak Demir, Esma Ozkan and Fulya Demircioglu Guneri
Neurosciences Journal October 2016, 21 (4) 331-337; DOI: https://doi.org/10.17712/nsj.2016.4.20160207
Vildan Binay Safer
From Ankara Physical Medicine Rehabilitation Training and Research Hospital, Ankara, Turkey
MD
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  • For correspondence: [email protected]
Sibel Ozbudak Demir
From Ankara Physical Medicine Rehabilitation Training and Research Hospital, Ankara, Turkey
MD
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Esma Ozkan
From Ankara Physical Medicine Rehabilitation Training and Research Hospital, Ankara, Turkey
MD
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Fulya Demircioglu Guneri
From Ankara Physical Medicine Rehabilitation Training and Research Hospital, Ankara, Turkey
MD
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  • Figure 1
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    Figure 1

    Gross motor function classification system levels of children with cerebral palsy at baseline.

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    Figure 2

    Modified Ashworh Scale levels of children with cerebral palsy at baseline. MAS - Modified Ashworh Scale

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    Figure 3

    The scores of a) CSHQ of children with cerebral palsy at multiple time points, b) Pittsburgh Sleep Quality Index of mothers at multiple time points, c) Beck Depression Inventory-II Turkish of mothers at multiple time points. CSHQ - Children’s Sleep Habits Questionnaire, PSQI - Pittsburgh Sleep Quality Index, BDI-II-TR - Beck Depression Inventory-II Turkish

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    Figure 4

    Total Children’s Sleep Habits Questionnaire subscale scores of children with cerebral palsy at multiple time points.

Tables

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    Table 1

    Characteristics of the children with cerebral palsy and mother.

    Children characteristicsBaselineTotal CSHQ score
    Age, mean±SD (years)7.05±2.69
    Weight, mean±SD (kg)23.51±9.95
    Sex Male/Female n (%)13 (54.2) / 11 (45.8)NS
    Gestation n (%)
     Preterm12 (50)
     37–42 weeks12 (50)NS
     Hearing impairment2 (8.3)NS
     Visual impairment5 (20.9)NS
     Cognitive impairment5 (20.9)NS
     Epilepsy10 (41.7)NS
     Urinary incontinence10 (41.7)NS
     Faecal incontinence12 (50)NS
     Night time splint use20 (83.3)NS
     Baclophen use4 (16.7)NS
    BoNT-A dose for UL1.63±3.59
    BoNT-A dose for LL8.87±4.13
    Total BoNT-A dose10.5±4.03
    Mother characteristics mean±SD
     Age, years33.46±8.08
     Education, years6.34±2.24
     Married22 (91.7)0.03*
    • CSHQ - Children’s Sleep Habits Questionnaire, BoNT-A - Botulinum toxin serotype A, UL - upper Limb, LL - lower limb, y - years, SD - standard deviations, n - numbers, NS - not significant,

    • ↵* Mann–Whitney U test

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    Table 2

    Changes over the time periods in the total CSHQ scores of children with cerebral palsy and PSQI and BDI-II-TR scores of mothers.

    VariablesBaselineFirst monthThird monthSixth monthp1p2p3
    Mean±SD
    Total CSHQ score49.29±6.4546.8±6.247.04±5.78248.13±5.551NSNSNS
    Bedtime resistance11.71±3.2610±2.7510.29±2.6910.58±2.450.009**NSNS
    Sleep onset delay1.5±0.721.17±0.481.13±0.341.21±0.41NSNSNS
    Sleep duration3.58±1.323.33±0.563.25±0.533.38±0.77NSNSNS
    Sleep anxiety8.0±2.577.13±2.277.25±2.547.29±2.330.046**NSNS
    Night waking4.83±1.054.46±1.284.92±1.285.33±1.4NSNSNS
    Parasomnia9.16±2.169.45±1.799.38±1.799.33±1.97NSNSNS
    Sleep disordered breathing3.58±0.933.5±0.723.54±0.883.71±0.91NSNSNS
    Day time sleepiness11.67±2.1410.25±1.9610.96±1.8312.0±2.650.007**NSNS
    PSQI6.29±3.244.08±2.344.79±2.656.13±3.33<0.001**0.028*NS
    BDI-II-TR10.13±10.237.25±6.275.58±4.226.46±3.99NS0.014**0.039**
    • CSHQ - Children’s Sleep Habits Questionnaire, PSQI - Pittsburgh Sleep Quality Index, BDI-II-TR - Beck Depression Inventory-II Turkish version, NS - not significant, p1 - baseline versus first month, p2 - baseline versus third month, p3 - baseline versus sixth month,

    • ↵* paired Student t-test;

    • ↵** related sample Wilcoxon signed-rank test

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Neurosciences Journal: 21 (4)
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Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression
Vildan Binay Safer, Sibel Ozbudak Demir, Esma Ozkan, Fulya Demircioglu Guneri
Neurosciences Journal Oct 2016, 21 (4) 331-337; DOI: 10.17712/nsj.2016.4.20160207

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Effects of botulinum toxin serotype A on sleep problems in children with cerebral palsy and on mothers’ sleep quality and depression
Vildan Binay Safer, Sibel Ozbudak Demir, Esma Ozkan, Fulya Demircioglu Guneri
Neurosciences Journal Oct 2016, 21 (4) 331-337; DOI: 10.17712/nsj.2016.4.20160207
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