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Demographic information DMD p-value Level 1 n=18 Level 2 n=17 Level 3 n=17 Healthy Group n=17 Mean±SD Age (months) 93.66±16.94 102.47±17.41 113.23±16.96 102.88±18.78 0.020* Height (cm) 119.00±9.80 123.41±9.46 127.76±9.51 126.35±11.72 0.079 Weight (kg) 25.72±5.44 27.26±6.88 31.58±8.32 30.35±9.75 0.110 BMI (kg/m2) 18.06±15.36 17.70±2.68 19.10±3.47 18.71±3.15 0.403 ↵* Level 1- Level 3 (p<0.0083 after the Bonferroni correction), BMI - body mass index, DMD - Duchenne Muscular Dystrophy, SD - Standard Deviation, cm - centimeter, m - meter, kg – kilogram
Parameters Mean±SD Upper Limit (%95 CI) Lower Limit (%95 CI) Min./Max. IQR Level 1 PCI (beat/m) 0.25±0.15 0.17 0.33 0.025/0.619 0.25 6MWT (m) 434.02±57.95 405.20 462.84 335/523 104.75 Ascending four stairs before 6MWT (sn) 2.59±0.91 2.14 3.05 1.17/4.61 1.38 Descending four stairs before 6MWT (sn) 2.07±0.55 1.79 2.35 1.13/2.91 0.91 Ten meters walk/run (sn) 4.75±0.75 4.38 5.13 3.60/6.12 1.22 Standing from supine (sn) 4.93±1.74 4.07 5.80 2.33/9.23 2.36 Level 2 PCI (beat/m) 0.34±0.20 0.24 0.45 0.089/0.752 0.37 6MWT (m) 367.44±63.34 334.35 400.52 255/490 81.50 Ascending four stairs before 6MWT (sn) 4.82±1.66 3.96 5.67 2.34/8.19 5.85 Descending four stairs before 6MWT (sn) 2.93±1.31 2.25 3.61 1.38/6.81 1.52 Ten meters walk/run (sn) 6.27±1.51 5.49 7.05 4.60/10.30 1.34 Standing from supine (sn) 8.09±2.52 6.80 9.39 3.51/12.06 4.41 Level 3 PCI (beat/m) 0.95±1.34 0.26 1.65 0.11/5.63 0.73 6MWT (m) 227.47±93.84 179.21 275.72 25/350 142.50 Ascending 4 stairs before 6MWT (sn) 20.53±11.25 14.75 26.32 4.31/40.80 6.69 Descending 4 stairs before 6MWT (sn) 10.83±8.70 6.36 15.31 4.31/40.80 6.69 Ten meters walk/run (sn) 12.98±8.24 8.74 17.22 7.62/43.12 5.55 Standing from supine (sn) 31.89±18.21 22.53 41.26 12.90/73 28.53 Healthy Group PCI (beat/m) 0.33±0.21 0.21 0.44 0.08/0.91 0.31 6MWT (m) 541.44±62.41 509.34 573.53 415/632 100 Ascending four stairs before 6MWT (sn) 1.41±0.30 1.25 1.57 1.00/2.16 0.35 Descending 4 stairs before 6MWT (sn) 1.22±0.30 1.06 1.37 0.86/1.90 0.35 Ten meters walk/run (sn) 3.23±0.46 2.99 3.47 2.38/4.19 0.43 Standing from supine (sn) 1.79±0.47 1.54 2.03 1.07/2.89 0.65 SD - Standard Deviation, PCI - Physiological Cost İndex, 6MWT - 6 Minute Walk Test, m - meter, sn – second
Parameters DMD Healthy Group Level 1 (Mean±SD) n=18 Z-value/ p-value Level 2 (Mean±SD)n=17 Z-value/ p-value Level 3 (Mean±SD) n=17 Z-value/ p-value (Mean±SD) n=17 Z-value/ p-value *Ascending 4 stairs before 6MWT (sn) 2.59±0.91 -2.699 0.007 4.82±1.66 -2.959 0.003 20.53±11.25 -3.053 0.002 1.41±0.30 -3.531 0.0001 *Ascending 4 stairs after 6MWT (sn) 2.96±1.08 5.32±1.73 24.63±14.09 1.72±0.36 *Descending 4 stairs before 6MWT (sn) 2.07±0.55 -2.179 0.029 2.93±1.31 -1.775 0.076 10.83±8.70 -2.320 0.020 1.22±0.30 -2.538 0.011 *Descending 4 stairs after 6MWT (sn) 2.33±0.81 3.15±1.35 12.31±10.55 1.40±0.44 *Standing from supine (sn) 4.93±1.74 8.09±1.52 31.89±18.21 1.78±0.47 *10 meters walk/run (sn) 4.75±0.75 6.27±1.51 12.98±8.24 3.23±0.46 *6MWT (m) 434.02±57.95 367.44±64.34 227.47±93.84 541.44±62.41 †PCI (beat/m) 0.25±0.157 0.34±0.205 0.95±1.349 0.30±0.21 *NSAA (0-34) 29.88±2.56 21.29±3.73 11.05±3.26 N/A