Research ArticleOriginal Article
Open Access

Expiratory muscle strength as a predictor of functional exercise capacity in generalized myasthenia gravis

Ebru Calik-Kutukcu, Yeliz Salci, Ecem Karanfil, Ayla Fil-Balkan, Can Ebru Bekircan-Kurt and Kadriye Armutlu
Neurosciences Journal April 2019, 24 (2) 95-100; DOI: https://doi.org/10.17712/nsj.2019.2.20180024

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Tables

  • Table 1

    Baseline patients with MG characteristics (n=28).

    VariablesMedian (min-max)
    OR (95% CI)
    Age (years)53.5 (24-65)
    Gender (male/female)13/15
    Height (cm)165.5 (153-181)
    Weight (kg)70 (40-103)
    BMI (kg/m2)25.00 (16.07-36.26)
    Disease duration (years)4 (1-18)
    The MGCS score10 (0-26)
    Fatigue severity (VAS)5 (0-10)

    • MG - Myasthenia gravis, OR - odds ratio, CI - confidence interval, BMI - body mass index, MGCS - myastenia gravis composite scale, VAS - visual analog scale

  • Table 2

    Pulmonary functions, strength and endurance of respiratory muscles and parameters of 6 minute walk test in patients with MG (n=28).

    VariablesMean±SD
    FEV1 (%)74.72±17.93
    FVC (%)71.60±16.71
    FEV1/FVC85.32±7.72
    VC (%)75.54±15.36
    MIP (cmH2O)81.86±22.85
    %MIP92.90±22.29
    MEP (cmH2O)90.21±37.49
    %MEP85.36±35.59
    6MWD (m)459.32±87.58
    %6MWD80.08±16.93
    6MWW32599.34±8112.72
    %Maximal HR67.23±12.85
    ∆HR (beats/min)27.29±18.38
    ∆SpO2 (%)-0.64±1.59
    ∆General fatigue (modified borg) Median (min-max)3 (0-10)
    Respiratory muscle endurance time (sec) Median (min-max)42.5 (11-180)

    • SD - standard deviation, MG - Myasthenia gravis, FEV1 - forced expiratory volume in one second, FVC - forced vital capacity, VC - vital capacity, MIP - maximal inspiratory pressure, MEP - maximal expiratory pressure, 6MWD - 6 minute walk test distance, 6MWW - six minute walk work, HR - heart rate, SpO2 - oxygen saturation.

  • Table 3

    The correlations between clinical status, pulmonary functions, respiratory muscle strength and functional capacity in patients with MG (n=28).

    VariablesFatigue severity (VAS)FEV1 (%)FVC (%)FEV1/FVC (%)VC (%)6MWD%6MWD6MWW
    The MGCS scorer=0.520*r=-0.552*r=-0.558*r=-0.546*r=-0.600*r=-0.464*r=-0.466*
    FVC (%)r=0.415*
    MIPr=0.586*r=0.377*
    MEPr=0.510*r=0.405*
    %MIPr=0.588*r=0.403*
    %MEPr=0.689*

    • MG - Myasthenia gravis, MGCS - myastenia gravis composite scale, VAS - visual analog scale, FEV1 - forced expiratory volume in one second, FVC - forced vital capacity, VC - vital capacity, MIP - maximal inspiratory pressure, MEP - maximal expiratory pressure, 6MWD - 6 minute walk test distance, 6MWW - six minute walk work, HR - heart rate,

    • ↵* p<0.05 Spearman correlation test.

  • Table 4

    Multiple linear regression analysis (n=28).

    Variables in the modelRR2Adjusted R2SE of the estimateBSEP-value
    %MIP, MEP, %MEP, The MGCS score0.7540.5680.49312.05656.18614.1670.001
    MEP, %MEP, The MGCS score0.7480.5600.50511.91763.4089.080<0.001
    %MEP, The MGCS score0.7310.5350.49811.99961.7049.022<0.001
    %MEP0.7020.4930.47312.28551.5666.128<0.001

    • Dependent variable: %6MWD, Independent variables: MEP, %MEP, %MIP, the MGCS, MGCS - myastenia gravis composite scale, MIP - maximal inspiratory pressure, MEP - Maximal expiratory pressure, SE - standard error, R2=0.493, F(1-27)=25.275, p<0.001, constant=51.566.

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