Research ArticleOriginal Article
Open Access

Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder

Hasan M. Aytac, Menekse S. Yazar, Ayse Erol and Sacide Pehlivan
Neurosciences Journal October 2021, 26 (4) 346-356; DOI: https://doi.org/10.17712/nsj.2021.4.20200050

Article Figures & Data

Tables

  • Table 1

    - The clinical characteristics of patients.

    CharacteristicsSchizophrenia n=118Bipolar disorder n=100
    Gendern (%)
    Female31 (26.3)58 (58)
    Male87 (73.7)42 (42)
    Treatment resistance
    No92 (77.9)76 (76)
    Yes26 (22.1)24 (24)
    MBL2
    AA87 (73.7)73 (73)
    AB23 (19.5)22 (22)
    BB8 (6.8)5 (5)
     MedianMedian
     (min-max)
    Age41(22-64)40.5(19-64)
    Age of onset (year)22(5-60)24(10-52)
    Duration of dis. (year)15.5(1-45)15(0.5-40)
    Number of Hospt.2(0-30)2(0-21)
    Last Hospt. (years ago)4(0.1-45)2(0.1-38)

    • min - minimum, max - maximum, dis - disease, hospt-hospitalization

  • Table 2

    - The scale scores of patients.

    SchizophreniaMedian(min-max)
    PANSS pos.11(7-24)
    PANSS neg.16(7-33)
    PANSS psycho.30(17-54)
    PANSS total58(33-102)
    SATCI14(0-18)
    CGI sev.5(3-7)
    CGI imp.2(1-4)
    Bipolar DisorderMedian(min-max)
    Manic episode2(0-25)
    Dep. episode1(0-12)
    Total episode4(1-27)
    HAM-D9(0-34)
    YMRS6(0-38)
    CGI sev.5(2-7)
    CGI imp.2(1-4)

    • min - minimum, max - maximum, PANSS - positive and negative syndrome scale, SATCI - schedule for assessing the three components of insight, CGI - clinical global impression scale, HAM-D - hamilton depression rating scale, YMRS - young mania rating scale, pos - positive, neg - negative, psycho - psychopathology, sev - severity, imp - improvement, dep - depressive, hist - history, cyc - cycling, postpart - postpartum

  • Table 3

    - Comparison of MBL2 genotype distribution of patients with the control group.

    GenotypeSchizophreniaControlOR95% CIP-value
    MBL2n= a(%)n=100 (%)   
    AA87 (73.7)64 (64)1.579*0.885-2.816*0.121*
    AB23 (19.5)35 (35)0.450*0.243-0.830*0.010*
    BB8 (6.8)1 (1)1.689&1.297-2.200&0.041&
    Allele
    A197 (83.5)163 (81.5)   
    B39 (16.5)37 (18.5)1.147&0.699-1.882&0.588&
    Bipolar Dis.
    MBL2n= b(%)n=100 (%)   
    AA73 (73)64 (64)1.521*0.834-2.775*0.171*
    AB22 (22)35 (35)0.532*0.284-0.995*0.047*
    BB5 (5)1 (1)5.211&0.598-45.426&0.212&
    Allele
    A168 (84)163 (81.5)   
    B32 (16)37 (18.5)1.192*0.709-2.004*0.508*

    • ↵a n-118,

    • ↵b n-100, OR - odds ratio, CI - confidence interval, Dis - Disorder,

    • ↵* Pearson chi-square,

    • ↵& Fisher’s Exact Test

  • Table 4

    - Comparison of MBL2 genotype distributions of schizophrenia or bipolar disorder patients with the same gender control group.

    GenotypeSchizophreniaControlOR95% CIP-value
    Malen=a (%)n=46 (%)   
    AA68 (78.2)31 (67.4)1.732*0.779-3.851*0.176*
    AB17 (19.5)15 (32.6)0.450*0.243-0.830*0.094*
    BB2 (2.3)0 (0)1.541&1.359-1.748&0.544&
    Allele
    A153 (87.9)77 (83.3)   
    B21 (12.1)15 (16.7)1.419*0.693-2.907*0.337*
    Femalen=b(%)n=54 (%)   
    AA19 (61.3)33 (61.1)1.008*0.407-2.494*0.987*
    AB6 (19.4)20 (37)0.408*0.143-1.164*0.089*
    BB6 (19.4)1 (1.9)12.720&1.453-111.378&0.009&
    Allele
    A44 (71)86 (79.6)   
    B18 (29)22 (20.4)0.625*0.304-1.286*0.200*
    Bipolar Dis. Malen=c(%)n=46 (%)   
    AA31 (73.8)31 (67.4)1.364*0.541-3.434*0.510*
    AB8 (19)15 (32.6)0.486*0.181-1.304*0.148*
    BB3 (7.1)0 (0)2.179&1.730-2.746&0.105&
    Allele
    A70 (83.3)77 (83.3)   
    B14 (16.7)15 (16.7)0.974&0.439-2.161&0.948&
    Femalen= d(%)n=54 (%)   
    AA42 (72.4)33 (61.1)1.670*0.755-3.696*0.204*
    AB14 (24.1)20 (37)0.541*0.239-1.224*0.138*
    BB2 (3.4)1 (1.9)1.893&0.167-21.494&1.000&
    Allele
    A98 (84.5)86 (79.6)   
    B18 (15.5)22 (20.4)1.393*0.701-2.768*0.343*

    • ↵a n=87,

    • ↵b n=31,

    • ↵c n=42,

    • ↵d n=58, Dis - disorder, OR - odds ratio, CI - confidence interval,

    • ↵* Pearson chi-square,

    • ↵& Fisher’s Exact Test

  • Table 5

    - Comparison of MBL2 genotype distributions of patients due to the resistance to treatment and clinical specifiers.

     NoYesOR95% CIP-value
    Treatment Resist.     
    Schizophrenia
    MBL2n= a(%)n=26 (%)   
    AA66 (71.7)21 (80.8)0.604*0.206-1.772*0.356*
    AB22 (23.9)1 (3.8)7.857*1.006-61.363*0.023*
    BB4 (4.4)4 (14.8)0.284&0.066-1.218&0.093&
    Allele
    A154 (84.1)43 (81.5)   
    B30 (15.9)9 (18.5)1.074*0.474-2.435*0.863*
    Bipolar Dis.
    MBL2n=b(%)n=24 (%)   
    AA51 (67.1)22 (91.7)0.185*0.040-0.852*0.018*
    AB21 (27.6)1 (4.2)8.782*1.114-69.197*0.016*
    BB4 (5.3)1 (4.2)1.278&0.136-12.015&1.000&
    Allele
    A123 (80.9)45 (93.8)   
    B29 (19.1)3 (6.3)0.283*0.082-0.974*0.035*
    Atypical Depres./Bipolar Dis.
    MBL2n=c(%)n=20 (%)   
    AA55 (68.8)18 (90)0.244*0.053-1.135*0.056*
    AB20 (25)2 (10)3.000&0.639-14.079&0.228&
    BB5 (6.3)0 (0)1.267&1.142-1.405&0.580&
    Allele
    A130 (81.2)38 (95)   
    B30 (18.8)2 (5)0.228*0.052-0.998*0.034*

    • ↵a n= 92,

    • ↵b n= 76,

    • ↵c n= 80, Resist-Resistance, OR- odds ratio, CI - confidence interval, Depres - depression,

    • ↵* Pearson chi-square,

    • ↵& Fisher’s exact test, Dis - disorder

  • Table 6

    - Comparison of scale scores and clinical parameters according to MBL2 genotype in patients with bipolar disorder.

     AAAB/BB**P-value
    Median (min-max)Median (min-max)
    HAM-D score10(0-34)9(2-25)0.479
    YMRS score4(0-38)7(0-28)0.207
    CGI sev.5(2-7)5(3-7)0.698
    CGI imp.2(1-4)2(1-4)0.847
    Manic episode2(0-21)3(1-25)0.512
    Dep. episode1(0-12)0(0-2)0.042
    Total episode4(1-23)3(1-27)0.329
    Duration of disease15(1-40)14(5-40)0.721
    Age of onset24(13-44)25(10-52)0.457
    Number of hospt.2(0-21)2(0-21)0.576

    • ↵**Mann Whitney U test, min - minimum, max - maximum, CGI - clinical global impression scale, HAM-D - hamilton depression rating scale, YMRS - young mania rating scale, sev. - severity, imp - improvement, dep -depressive; hospt - hospitalization

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