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Research ArticleOriginal Article
Open Access

Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients

Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu and Yan Xing
Neurosciences Journal July 2022, 27 (3) 143-149; DOI: https://doi.org/10.17712/nsj.2022.3.20210109
Zhe Shi
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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  • For correspondence: [email protected]
Yonghui Wu
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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Lei Su
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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Ying Zhou
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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Lan Zhang
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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Da Xu
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD
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Yan Xing
From Department of Neurology (Xing, Shi, Su, Zhou, Zhang, Xu D), from the Department of Cardiology (Wu Y), Aviation General Hospital, People’s Republic of China, Beijing,
MD, PhD
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    Figure 1

    - Crisis triggers in RLS patients with different shunt sizes. A) Crisis triggers among MA+ patients with different sizes of shunts. B) Crisis triggers among MA- patients with different sizes of shunts. RLS - right-to-left shunt, MA - migraine patients without aura

Tables

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    • View popup
    Table 1

    - The type and size of RLS and other clinical features of pain in migraine patients with or without aura.

    VariablesMA+(n=134)MA–(n=394)P-value
    Age35.89±13.7037.05±12.070.317
    Sex (Male: Female)43:91113:2800.465
    Family history of migraine, n (%)49 (36.57)142 (36.04)0.913
    Age of onset25.45±12.9928.04±11.730.032
    Yearly frequency of pain21.75±17.4622.73±18.110.585
    Duration of pain (hours)13.18±6.3812.11±5.970.078
    Degree of pain6.35±1.605.89±1.760.007
    Type of RLS, n (%)
    Without RLS53 (39.55)183 (46.4)0.201
    Latent RLS38 (28.36)127 (21.3) 
    Permanent RLS43 (32.09)84 (32.2) 
    Size of shunts, n (%)
    Without RLS53 (39.55)183 (46.45)0.324
    Mild of RLS37 (27.61)113 (28.68) 
    Moderate of RLS14 (10.45)32 (8.12) 
    Massive of RLS30 (22.39)66 (16.75) 
    Photophobia, n (%)37 (27.61)36 (9.14)<0.001
    Phonophobia, n (%)34 (25.37)35 (8.88)<0.001

    RLS - right-to-left shunt, MA - migraine patients without aura

      • View popup
      Table 2

      - The clinical features of pain in MA+ patients with or without RLS.

      VariablesMA+RLS+ (n=81)MA+RLS- (n=53)P-value
      Age36.72±12.9334.40±14.810.151
      Sex (Male: Female)21:6022:310.059
      Family history of migraine, n (%)32 (39.51)17 (32.08)0.383
      Age of onset24.46±12.4426.96±13.750.169
      Yearly frequency of pain23.32±17.3419.34±17.520.703
      Duration of pain (hours)12.99±6.3813.47±6.450.177
      Degree of pain6.41±1.526.26±1.720.196
      Photophobia, n (%)14 (17.28)23 (43.40)0.001
      Phonophobia, n (%)13 (16.05)21 (39.62)0.002

      RLS - right-to-left shunt, MA - migraine patients without aura

        • View popup
        Table 3

        - Difference of clinical features in MA+RLS+ patients with different shunts size (n=81).

        VariablesSize of shunts, n (%)P-value
        Mild of RLSModerate of RLSMassive of RLS
        Gender, n (%)
        Male, 21 (25.93)8 (9.87)1 (1.23)12 (14.81)0.049
        Female, 60 (74.07)29 (35.80)13 (16.05)18 (22.22) 
        Location of headache
        Left9 (11.11)4 (4.94)9 (11.11)0.474
        Right11 (13.58)7 (8.64)8 (9.88) 
        Bilateral17 (20.99)3 (3.70)13 (16.05) 
        Age of onset26.73±14.2723.64±11.3322.03±10.200.300
        Yearly frequency of pain27.38±17.3525.14±17.9217.47±15.930.059
        Duration of pain (hours)11.51±5.4911.79±4.7615.37±7.430.034
        Degree of pain6.62±1.465.64±1.346.50±1.610.112
        Photophobia7 (18.92)3(21.43)4(13.33)0.754
        Phonophobia7 (18.92)2(14.29)4(13.33)0.809
        • View popup
        Table 4

        - The clinical features of pain in MA- patients with or without RLS.

        VariablesMA-RLS+ (n=211)MA-RLS- (n=183)P-value
        Age36.57±11.9137.61±12.250.739
        Gender (Male: Female)56:15558:1250.261
        Family history of migraine, n (%)79 (37.44)63 (34.43)0.534
        Age of onset27.24±11.6528.97±11.790.740
        Yearly frequency of pain23.07±17.4522.34±18.890.249
        Duration of pain (hours)11.82±5.7012.44±6.280.143
        Degree of pain5.94±1.775.82±1.760.694
        Photophobia, n (%)26 (12.32)10 (5.46)0.018
        Phonophobia, n (%)26 (12.32)9 (4.92)0.010
        • View popup
        Table 5

        - Difference of clinical features in MA-RLS+ patients with different shunts size (n=211).

        VariablesSize of shunts, n (%)P-value
        Mild of RLSModerate of RLSMassive of RLS
        Gender, n (%)
        Male, 56 (26.50)30(14.22)8 (3.79)18 (8.53)0.972
        Female, 155 (73.50)83 (39.34)24(11.37)48 (22.75) 
        Location of headache
        Left28 (13.33)13 (6.19)18 (8.57)0.547
        Right22 (10.48)5 (2.38)12 (5.71) 
        Bilateral62 (29.52)14 (6.67)36 (17.14) 
        Age of onset27.54±12.7028.56±9.7426.09±10.620.571
        Yearly frequency of pain22.19±17.3921.22±14.5725.45±18.790.393
        Duration of pain (hours)10.83±5.4813.16±5.0412.85±6.100.025
        Degree of pain5.80±1.606.16±1.666.09±2.070.426
        Photophobia, n (%)8 (7.08)6 (18.75)12 (18.18)0.045
        Phonophobia, n (%)8 (7.08)6 (18.75)12 (18.18)0.045
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      Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients
      Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu, Yan Xing
      Neurosciences Journal Jul 2022, 27 (3) 143-149; DOI: 10.17712/nsj.2022.3.20210109

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      Relationship between right-to-left shunt detected by c-TCD and clinical characteristics in migraine patients
      Zhe Shi, Yonghui Wu, Lei Su, Ying Zhou, Lan Zhang, Da Xu, Yan Xing
      Neurosciences Journal Jul 2022, 27 (3) 143-149; DOI: 10.17712/nsj.2022.3.20210109
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