Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • Saudi Medical Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Neurosciences Journal
  • Other Publications
    • Saudi Medical Journal
  • My alerts
  • Log in
Neurosciences Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
ReviewReview Article
Open Access

The consequences of sleep deprivation on cognitive performance

Mohammad A. Khan and Hamdan Al-Jahdali
Neurosciences Journal April 2023, 28 (2) 91-99; DOI: https://doi.org/10.17712/nsj.2023.2.20220108
Mohammad A. Khan
College of Medicine (Khan, Al-Jahdali), King Saud bin Abdulaziz University for Health Sciences, from King Abdullah International Medical Research Center (Khan, Al-Jahdali), and from Department of Medicine, Pulmonary Division, Ministry of National Guard-Health Affairs (Khan, Al-Jahdali), Riyadh, Kingdom of Saudi Arabia.
MD, MRCP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hamdan Al-Jahdali
College of Medicine (Khan, Al-Jahdali), King Saud bin Abdulaziz University for Health Sciences, from King Abdullah International Medical Research Center (Khan, Al-Jahdali), and from Department of Medicine, Pulmonary Division, Ministry of National Guard-Health Affairs (Khan, Al-Jahdali), Riyadh, Kingdom of Saudi Arabia.
MD, MRCP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Figure 1
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1

    - Comparison of the connections between the mPFC and amygdala, as well as the amygdala and the locus coeruleus, during normal sleep vs SD. SD - Sleep deprivation, mPFC - medial prefrontal cortex

  • Figure 2
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2

    - An overview of signaling pathways in the hippocampus following sleep deprivation. The dashed arrows demonstrate a reduction of a signaling pathway. (A) Altered glutamatergic signaling. disrupted cAMP signaling. (C) Down regulated mTOR signaling. Figure adapted from Prince and Abel14

  • Figure 3
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3

    - Areas affected by SD (A) Areas of the brain affected by sleep deprivation, affecting alertness, memory and attentional performance. (B) In a SD state, there is unstable inhibition concerning task-related DMN and FPN activity, as well as inconsistent increasing arousal influencing activity in the thalamus. This leads to irregular signals of DMN activity and reduced FPN activity during tasks. This can lead to weakened attentiveness and working-memory functioning, becoming better with greater thalamic activity and poorer with reduced thalamic activity. Figure adapted from Krause et al54

  • Figure 4
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4

    - The synaptic homeostasis hypothesis. Throughout wakefulness, cortical synapses potentiate relative to activity, giving a net rise in synaptic power and a reduction is signal/noise ratio. This synaptic potentiation is linked with an escalation in slow-wave activity (SWA) in NREM sleep, where synaptic renormalization and downscaling occurs, with an increase in signal/noise ratio. This mechanism can permit additional synaptic plasticity to happen the resulting day alongside avoiding the metabolic downsides linked with excitability and extreme potentiation through wakefulness. Figure adapted from Rantamäki and Kohtala.37

  • Figure 5
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5

    - Impaired glymphatic system in the brain after sleep deprivation. Lower AQP4 expression, altered glymphatic clearance, toxic waste buildup, and higher beta-amyloid levels occur, leading to a dysfunction in cognitive performance.

PreviousNext
Back to top

In this issue

Neurosciences Journal: 28 (2)
Neurosciences Journal
Vol. 28, Issue 2
1 Apr 2023
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Neurosciences Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The consequences of sleep deprivation on cognitive performance
(Your Name) has sent you a message from Neurosciences Journal
(Your Name) thought you would like to see the Neurosciences Journal web site.
Citation Tools
The consequences of sleep deprivation on cognitive performance
Mohammad A. Khan, Hamdan Al-Jahdali
Neurosciences Journal Apr 2023, 28 (2) 91-99; DOI: 10.17712/nsj.2023.2.20220108

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The consequences of sleep deprivation on cognitive performance
Mohammad A. Khan, Hamdan Al-Jahdali
Neurosciences Journal Apr 2023, 28 (2) 91-99; DOI: 10.17712/nsj.2023.2.20220108
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Structural and functional changes in the hippocampus induced by environmental exposures
  • Tumefactive demyelinating lesions: A literature review of recent findings
  • Epilepsia partialis continua: A review
Show more Review Article

Similar Articles

Navigate

  • home

More Information

  • Help

Additional journals

  • All Topics

Other Services

  • About

© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

Powered by HighWire