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Autoimmune epilepsy, retrospective case series of clinical features, management, and outcomes

Abrar A. Khan, Waleed M. Alzahrani, Reem M. Bagadood, Baker M. Alweshah, Jwana F. Alsulaimi and Hanadi M. Abualela
Neurosciences Journal October 2023, 28 (4) 264-269; DOI: https://doi.org/10.17712/nsj.2023.4.20230007
Abrar A. Khan
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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  • For correspondence: [email protected]
Waleed M. Alzahrani
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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Reem M. Bagadood
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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Baker M. Alweshah
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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Jwana F. Alsulaimi
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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Hanadi M. Abualela
From the Department of Neurology (khan, Alzahrani, Bagadood, Abualela), and from the Department of Neurophysiology (Alweshah, Alsulaimi), King Abdullah Medical City, Makkah Al-Mukarramah, Kingdom of Saudi Arabia
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    Figure 1

    - Brain magnetic resonance imaging (MRI) demonstrating abnormal bilateral hippocampal volume loss more pronounced on the right side.

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    Figure 2

    - Interictal EEG showing diffuse slowing with a delta brush, a pattern characteristic of autoimmune encephalopathy associated with Anti-NMDA antibody.

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    Table 1

    - Clinical characteristics.

    Patient/Sex/AgeInitial symptomEEG abnormalitiesMRI findingCSF abnormalityAutoantibody profileImmune therapy
    1/24/FGeneralized tonic-clonic seizureMultiple independent bitemporal sharp waves, maximum left temporal and left frontal waves.bilateral mesial temporal sclerosisPositive oligoclonal band.GAD65Steroid, Rituximab
    2/19/FPsychiatric symptoms, Status epilepticus after an acute febrile illnessDiffuse slowing with delta brushunremarkableHigh protein levelNMDARSteroid, plasma exchange, IVIG, Rituximab.
    3/53/FMusicogenic SeizureIntermittent rhythmic sharp wave bitemporal area, maximum right.unremarkableNormalGAD65Steroid, IVIG, Rituximab.
    4/38/FCognitive dysfunction, focal and generalized seizureIndependent bitemporal epileptiform dischargesRight mesial temporal sclerosisHigh protein levelGAD65Rituximab.
    5/35/FGeneralized tonic-clonic seizureIndependent bitemporal sharp wavesunremarkableNormalNMDARAdalimumab, Azathioprine.
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Neurosciences Journal: 28 (4)
Neurosciences Journal
Vol. 28, Issue 4
1 Oct 2023
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Autoimmune epilepsy, retrospective case series of clinical features, management, and outcomes
Abrar A. Khan, Waleed M. Alzahrani, Reem M. Bagadood, Baker M. Alweshah, Jwana F. Alsulaimi, Hanadi M. Abualela
Neurosciences Journal Oct 2023, 28 (4) 264-269; DOI: 10.17712/nsj.2023.4.20230007

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Autoimmune epilepsy, retrospective case series of clinical features, management, and outcomes
Abrar A. Khan, Waleed M. Alzahrani, Reem M. Bagadood, Baker M. Alweshah, Jwana F. Alsulaimi, Hanadi M. Abualela
Neurosciences Journal Oct 2023, 28 (4) 264-269; DOI: 10.17712/nsj.2023.4.20230007
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