Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population

Article Figures & Data

Table 1

- The clinical characteristics of SCZ patients.

SCZ - schizophrenia, SD - standart deviation, dis. - disease, hospt. - hospitalization

Table 2

- Comparison of frequencies of IL-2 (rs2069762) gene variants between patients with SCZ and healthy controls.

IL-2	Genotype	SCZ	Healthy control	OR	95% CI	P-value
		n= ^{^a} (%)	n=100 (%)
Recessive	GG	25 (19.7)	10 (10)	0.453^{^*}	0.207-0.995^{^*}	0.045^{^*}
Over-dominant	GT	13 (10.2)	12 (12)	0.836^{^*}	0.364-1.923^{^*}	0.673^{^*}
Dominant	TT	89 (70.1)	78 (78)	0.661^{^*}	0.360-1.212^{^*}	0.179^{^*}
Additive	GG vs TT			2.191^{^*}	0.991-4.846^{^*}	0.049^{^*}
	G	50 (19.7)	32 (16)
	T	204 (90.3)	168 (84)	1.287^{^*}	0.790-2.097^{^*}	0.311^{^*}

OR - odd ratio, CI - confident interval,

Table 3

- Comparison of frequencies of IL-2RA (rs2104286) gene variants between patients with SCZ and healthy controls.

IL-2RA	Genotype	SCZ	Healthy control	OR	95% CI	P-value
		n= ^{^a} (%)	n=100 (%)
Recessive	AA	22 (17.3)	13 (13)	1.402^{^*}	0.668-2.945^{^*}	0.371^{^*}
Over-dominant	AG	104 (81.9)	86 (86)	0.736^{^*}	0.357-1.517^{^*}	0.405^{^*}
Dominant	GG	1 (0.8)	1 (1)	0.786^{^&}	0.049-12.719^{^&}	1.000^{^&}
Additive	AA vs GG			1.692^{^&}	0.097-29.413^{^&}	1.000^{^&}
	A	148 (58.3)	112 (56)
	G	106 (41.7)	88 (44)	1.097^{^*}	0.754-1.595^{^*}	0.628^{^*}

OR - odd ratio, CI - confident interval,

Table 4

- Interaction of IL-2 (rs2069762), and IL-2RA (rs2104286) polymorphisms on SCZ risk.

IL-2 (rs2069762)	IL-2RA (rs2104286)	SCZ (%)	Control (%)	OR (95%CI)	P-value
GT	AG	9 (7.1)	10 (10.0)	0.686 (0.268 – 1.760)^{^*}	0.431^{^*}
GT	AA	4 (3.1)	2 (2.0)	1.593 (0.286 – 8.881)^{^&}	0.697^{^&}
GT	GG	0 (0.0)	0 (0.0)	-	-
TT	AG	72 (56.7)	67 (67.0)	0.645 (0.374 – 1.112)^{^*}	0.114^{^*}
TT	AA	16 (12.6)	11 (11.0)	1.116 (0.515 – 2.639)^{^*}	0.712^{^*}
TT	GG	1 (0.8)	0 (0.0)	1.794 (1.597 – 2.015)^{^*}	1.000^{^*}
GG	AG	23 (18.1)	9 (9.0)	2.236 (0.984 – 5.079)^{^*}	0.050^{^*}
GG	AA	2 (1.6)	0 (0.0)	1.800 (1.601 – 2.023)^{^&}	0.505^{^&}
GG	GG	0 (0.0)	1 (1.0)	2.283 (1.969 – 2.642)^{^&}	0.441^{^&}