Research ArticleOriginal Article
Open Access

Perioperative and postoperative effects of hydrostatic pressure applied to the dura mater on central nervous system in unilateral biportal endoscopic spine surgery

Eralp Çevikkalp, Hayati Aygün, Kadri Yıldız and Esra Mercanoğlu Efe
Neurosciences Journal October 2024, 29 (4) 239-245; DOI: https://doi.org/10.17712/nsj.2024.4.20230123

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Tables

  • Table 1

    - Change in right ONSD measurements by time.

    TimeMedian (Min-Max)P-value*
    T1 ONSD4.4 (3.9-5.7)<0.001a
    T2 ONSD4.1 (3.5-5.2)
    T3 ONSD5.3 (4.2-6.0)
    T4 ONSD4.2 (3.5-5.2)
    T5 ONSD4.5 (3.9-5.8)
    aPost hoc comparisons: All significant, except for paired comparisons of T1-T5 and T2-T4
    T1 ETD22.0 (20.4-25.0)<0.001b
    T2 ETD22.0 (19.0-24.8)
    T3 ETD22.0 (20.0-24.0)
    T4 ETD22.0 (18.0-24.5)
    T5 ETD21.9 (19.5-25.3)
    bPost hoc comparisons: Paired comparisons of T1-T2 and T1-T4 are significant
    T1 ONSD/ETD ratio0.20 (0.18-0.25)<0.001a
    T2 ONSD/ETD ratio0.18 (0.16-0.24)
    T3 ONSD/ETD ratio0.24 (0.19-0.27)
    T4 ONSD/ETD ratio0.19 (0.17-0.24)
    T5 ONSD/ETD ratio0.21 (0.18-0.27)

    ONSD, optic nerve sheath diameter; ETD, eyeball transverse diameter.

    • ↵a Post hoc comparisons: All significant, except for paired comparisons of T1-T5 and T2-T4,

    • ↵* Freidman test.

  • Table 2

    - Change in left ONSD measurements by time.

    TimeMedian (Min-Max)P-value*
    T1 ONSD4.4 (3.9-5.7)<0.001a
    T2 ONSD4.1 (3.6-5.2)
    T3 ONSD5.3 (4.2-6.0)
    T4 ONSD4.3 (3.5-5.2)
    T5 ONSD4.5 (3.9-5.8)
    T1 ETD22.0 (20.0-25.3) 5.3<0.001b
    T2 ETD22.0 (19.2-24.8) 5.6
    T3 ETD22.0 (19.5-24.0)
    T4 ETD22.0 (20.0-24.5) 4.5
    T5 ETD22.0 (19.5-25.3) 5.8
    T1 ONSD/ETD ratio0.20 (0.17-0.25)<0.001c
    T2 ONSD/ETD ratio0.19 (0.16-0.24) 
    T3 ONSD/ETD ratio0.24 (0.19-0.27) 
    T4 ONSD/ETD ratio0.19 (0.17-0.24) 
    T5 ONSD/ETD ratio0.21 (0.18-0.27) 

    ONSD, optic nerve sheath diameter; ETD, eyeball transverse diameter,

    • * Freidman test.

    • ↵a Post hoc comparisons: All significant, except for paired comparison of T1-T5,

    • ↵b Post hoc comparisons: Paired comparisons of T1-T2, T1-T4, and T1-T5 are significant,

    • ↵c Post hoc comparisons: All significant. except for paired comparisons of T1-T4 and T2-T4

  • Table 3

    - The ONSD measurements by headache development.

    TimeHeadacheP-value*
    NoYes
    Median (Min-Max)Median (Min-Max)
    Right
    T3 ONSD5.1 (4.2-6.0)5.6 (5.2-6.0)<0.001
    T3 ETD22.0 (20.0-24.0)22.0 (21.0-23.0)0.513
    T3 ONSD/ETD ratio0.23 (0.19-0.27)0.25 (0.23-0.27)<0.001
    Left
    T3 ONSD5.1 (4.2-5.9)5.6 (5.2-6.0)<0.001
    T3 ETD22.0 (19.5-24.0)22.0 (21.0-23.0)0.627
    T3 ONSD/ETD ratio0.23 (0.19-0.27)0.25 (0.23-0.27)<0.001

    ONSD, optic nerve sheath diameter; ETD, eyeball transverse diameter.

    • ↵* Mann-Whitney U test.

  • Table 4

    - Threshold value for ONSD values for the development of headache (ROC curve analysis).

    THVAUC95% CIp-valueSenSpePPVNPV
    Lower limitUpper limit
    5.30.8300.7610.899<0.00187.571.950.994.5

    THV, threshold value; AUC, area under the curve; CI, confidence interval; Sen, sensitivity, Spe, Specificity; PPV, positive predictive value; NPV, negative predictive value.

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