Warfarin induced skin necrosis in a patient with craniopharyngioma

Abstract

Oral anticoagulants are associated with several adverse skin manifestations ranging from ecchymosis, purpura, and hemorrhagic necrosis to maculopapular rash, vesicular urticarial eruptions and purple toes. Skin necrosis is a rare but serious side effect of warfarin therapy, associated with significant morbidity and mortality. The prevalence of warfarin induced skin necrosis (WISN) is 0.01-0.1%. We report a 20-year-old female patient of craniopharyngioma who developed WISN following postoperative femoropopliteal deep vein thrombosis.