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Research ArticleORIGINAL ARTICLES
Open Access

Neuroprotective effects of selenium and ginkgo biloba extract (EGb761) against ischemia and reperfusion injury in rat brain

Guven Erbil, Seda Ozbal, Ulker Sonmez, Cetin Pekcetin, Kazim Tugyan, Alper Bagriyanik and Candan Ozogul
Neurosciences Journal July 2008, 13 (3) 233-238;
Guven Erbil
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Seda Ozbal
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Ulker Sonmez
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Cetin Pekcetin
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Kazim Tugyan
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Alper Bagriyanik
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Candan Ozogul
Department of Histology and Embryology, School of Medicine, Dokuz Eylul University Inciralti, Izmir, Turkey. Tel. +90 (532) 6777949. Fax. +90 (232) 2590541. E-mail address: [email protected]
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Abstract

OBJECTIVE: To determine the neuroprotective effects of Ginkgo biloba extract (EGb761) and Selenium (Se), and the combination of these agents on ischemia/reperfusion (I/R) injury in a rat model of transient global cerebral I/R.

METHODS: This experimental study took place in the Animal Research Laboratory at Dokuz Eylul University, Izmir, Turkey in the year 2006. Fifty rats were subjected to cerebral I/R induced by right carotid artery occlusion technique for a duration of 45 minutes, and then were treated with EGb761 (50 mg/kg/day, ip) and Se (0.625 mg/kg, ip), alone or in combination for 14 days after surgery. Superoxide dismutase, and glutathione peroxidase activities were measured in the hippocampal tissues from 25 animals. Histopathological examinations were also carried out under light and electron microscopy from the rest of animals.

RESULTS: The results suggest that EGb761 has a potent neuroprotective effect against cerebral I/R induced injury in rat brain that is comparable with that of Se. However, the combined use of EGb761 and Se does not further protect from neuronal injury when compared with the use of both agents alone.

CONCLUSION: Our results suggest that administration of EGb761, Se and its combination with EGb761 have significant neuroprotective effects on I/R injury in rats via suppression of oxidative stress.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 13 (3)
Neurosciences Journal
Vol. 13, Issue 3
1 Jul 2008
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Neuroprotective effects of selenium and ginkgo biloba extract (EGb761) against ischemia and reperfusion injury in rat brain
Guven Erbil, Seda Ozbal, Ulker Sonmez, Cetin Pekcetin, Kazim Tugyan, Alper Bagriyanik, Candan Ozogul
Neurosciences Journal Jul 2008, 13 (3) 233-238;

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Neuroprotective effects of selenium and ginkgo biloba extract (EGb761) against ischemia and reperfusion injury in rat brain
Guven Erbil, Seda Ozbal, Ulker Sonmez, Cetin Pekcetin, Kazim Tugyan, Alper Bagriyanik, Candan Ozogul
Neurosciences Journal Jul 2008, 13 (3) 233-238;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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