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Research ArticleORIGINAL ARTICLES
Open Access

Which is more effective in reducing secondary brain damage resulting from cyclooxygenase expression following traumatic brain injury: calcium channel blockers or cox inhibitors?

Hamit S. Karabekir, Canan Balci, Fatma Aktepe, Cigdem Tokyol and Husniye Dilek
Neurosciences Journal July 2008, 13 (3) 239-243;
Hamit S. Karabekir
Department of Neurosurgery, School of Medicine, Afyon Kocatepe University, Maresal Cakmak Mah, Suhut Kavsagi, Kardelen Sitesi D Blok Kat:2 D:12 03100, Afyonkarahisar, Turkey. Tel. +90 (272) 2142065. Fax. +90 (272) 2133066. E-mail: [email protected] / [email protected]
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Canan Balci
Department of Neurosurgery, School of Medicine, Afyon Kocatepe University, Maresal Cakmak Mah, Suhut Kavsagi, Kardelen Sitesi D Blok Kat:2 D:12 03100, Afyonkarahisar, Turkey. Tel. +90 (272) 2142065. Fax. +90 (272) 2133066. E-mail: [email protected] / [email protected]
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Fatma Aktepe
Department of Neurosurgery, School of Medicine, Afyon Kocatepe University, Maresal Cakmak Mah, Suhut Kavsagi, Kardelen Sitesi D Blok Kat:2 D:12 03100, Afyonkarahisar, Turkey. Tel. +90 (272) 2142065. Fax. +90 (272) 2133066. E-mail: [email protected] / [email protected]
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Cigdem Tokyol
Department of Neurosurgery, School of Medicine, Afyon Kocatepe University, Maresal Cakmak Mah, Suhut Kavsagi, Kardelen Sitesi D Blok Kat:2 D:12 03100, Afyonkarahisar, Turkey. Tel. +90 (272) 2142065. Fax. +90 (272) 2133066. E-mail: [email protected] / [email protected]
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Husniye Dilek
Department of Neurosurgery, School of Medicine, Afyon Kocatepe University, Maresal Cakmak Mah, Suhut Kavsagi, Kardelen Sitesi D Blok Kat:2 D:12 03100, Afyonkarahisar, Turkey. Tel. +90 (272) 2142065. Fax. +90 (272) 2133066. E-mail: [email protected] / [email protected]
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Abstract

OBJECTIVE: To evaluate localizations of cyclooxygenase (COX)-1 and COX-2 following traumatic brain injury (TBI) and the effects of 2 therapeutic agents on COX inhibition.

METHODS: Forty rabbits were used in this study for developing a TBI model and divided into 4 groups (n=10) at Afyon Kocatepe University School of Medicine, Afyonkarahisar, Turkey in June 2004. Differential cellular COX-1 and COX-2 protein expression profiles were analyzed following TBI, and the effects of 2 therapeutic agents, indomethacin and nimodipine, on COX inhibition were evaluated immunohistochemically.

RESULTS: This study revealed that COX-1 and COX-2 protein expression were significantly increased in vascular endothelial, smooth muscle cells, and CD68+ microglia/macrophages following TBI. Indomethacin inhibited the COX expression in glial cells more than nimodipine, however, both did not affect endothelial COX-1 and COX-2 expression.

CONCLUSION: The restricted accumulation of COX-1 at the perilesional area points to an acute inflammatory response and the role of COX-1 in TBI. This study revealed that COX-1 expression should be a pharmacological target following TBI, and COX-2 should also be evaluated in this aspect, and indomethacin is more effective than nimodipine for blocking COX-1.

  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Neurosciences Journal: 13 (3)
Neurosciences Journal
Vol. 13, Issue 3
1 Jul 2008
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Which is more effective in reducing secondary brain damage resulting from cyclooxygenase expression following traumatic brain injury: calcium channel blockers or cox inhibitors?
Hamit S. Karabekir, Canan Balci, Fatma Aktepe, Cigdem Tokyol, Husniye Dilek
Neurosciences Journal Jul 2008, 13 (3) 239-243;

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Which is more effective in reducing secondary brain damage resulting from cyclooxygenase expression following traumatic brain injury: calcium channel blockers or cox inhibitors?
Hamit S. Karabekir, Canan Balci, Fatma Aktepe, Cigdem Tokyol, Husniye Dilek
Neurosciences Journal Jul 2008, 13 (3) 239-243;
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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