Research ArticleOriginal Article
Open Access

Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats

Salim S. Al-Rejaie, Hatem M. Abuohashish, Mohammed M. Ahmed, Aws S. Arrejaie, Abdulaziz M. Aleisa and Shakir D. AlSharari
Neurosciences Journal April 2015, 20 (2) 115-123; DOI: https://doi.org/10.17712/nsj.2015.2.20140511

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Figures

  • Figure 1
    Figure 1

    Effect of telmisartan on body weights of normal and diabetic male Wistar albino rats. Data are expressed as mean± S.E and analyzed using 2 way ANOVA followed by Bonferroni post hoc test. Six rats were used in each group. ***acontrol versus STZ group. TMT - Telmisartan, STZ - Streptozotocin, Cont - control, S.E - standard error

  • Figure 2
    Figure 2

    Effect of telmisartan treatment on diabetic male Wistar albino rats post-treatment blood glucose levels. Data are expressed as Mean± S.E. and analyzed using one-way ANOVA followed by Newman-Keuls post hoc test. Six rats were used in each group. ***a Cont vs STZ group. TMT - Telmisartan, STZ - Streptozotocin, Cont - control, S.E - standard error

  • Figure 3
    Figure 3

    Effect of telmisartan on A) pain threshold in paw pressure analgesia, B) rota rod performance, and C) tail withdrawal latency rate in diabetic and non-diabetic animals. Data are expressed as mean±S.E. (n=6) and analyzed using 2 way ANOVA followed by Bonferroni post hoc test. The significance different compared to post-treated and pre-treated expressed as p-values. ***a, **acomparison between the diabetic and non-diabetic and **bcomparison between TMT treated to diabetic rats to untreated diabetic animals. TMT - Telmisartan, STZ - Streptozotocin, Cont - control, S.E - standard error

  • Figure 4
    Figure 4

    Effect of telmisartan on nerve growth factor (NGF) levels in sciatic nerve of normal and diabetic male Wistar albino rats. Data are expressed as mean±S.E. and analyzed using one-way ANOVA followed by Newman-Keuls post hoc test. Six rats were used in each group. **aCont vs STZ group; *bSTZ vs diabetic TMT treated groups. TMT - Telmisartan, STZ - Streptozotocin, Cont - control, S.E - standard error

  • Figure 5
    Figure 5

    Effects of telmisartan on the histopathological features of sciatic nerves in diabetic and non-diabetic animals A) normal histology of sciatic nerve fibers in control animal, B) scattered degenerated bodies with loss of myelin sheath and inflammatory infiltrate along the nerve fibers in diabetic untreated group, C) few degenerated nerve bodies with focal loss of myelin sheath in STZ+TMT5 group, and D) lower degree of inflammatory cells infiltrate and degenerated bodies in STZ+TMT10 group. TMT - Telmisartan, STZ - Streptozotocin

  • Figure 6
    Figure 6

    Effect of telmisartan on serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in diabetic and non-diabetic male Wistar albino rats. Data are expressed as mean±S.E. and analyzed using one way ANOVA followed by Newman-Keuls post hoc test. Six rats were used in each group. *aCont versus STZ group; *bSTZ versus diabetic TMT treated groups. TMT - Telmisartan, STZ - Streptozotocin, Cont - control, S.E - standard error

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