Research ArticleOriginal Article
Open Access

Exogenous human urinary kallidinogenase increases cerebral blood flow in patients with acute ischemic stroke

Jing Miao, Fang Deng, Ying Zhang, Hong Y. Xie and Jia C. Feng
Neurosciences Journal April 2016, 21 (2) 126-130; DOI: https://doi.org/10.17712/nsj.2016.2.20150581

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    Comparison of NIHSS scores between the HUK-treated experimental group and the control group. NIHSS - National Institutes of Health Stroke Scale; ΔNIHSS (fourteenth day) - NIHSS (first day); *p<0.05, experimental group versus control group

  • Figure 2
    Figure 2

    Experimental group images showing: A) and B) early-stage stroke, with new infarction revealed by DWI (arrow), artery stenosis shown by MRA (arrow), and artery ischemia shown by MRP (arrow). C) and D) post-treatment images showing clear improvements in the corresponding areas (arrows). DWI - diffusion weighted magnetic resonance imaging, MRA - magnetic resonance angiography, MRP - magnetic resonance perfusion weighted imaging

  • Figure 3
    Figure 3

    Control group images showing: A) and B) early-stage stroke with new infarction revealed by DWI (arrow), artery stenosis shown by MRA (arrow), and artery ischemia shown by MRP (arrow). C) and D) post-treatment images showing little improvement in the corresponding areas (arrows). DWI - diffusion weighted magnetic resonance imaging, MRA - magnetic resonance angiography, MRP - magnetic resonance perfusion weighted imaging

Tables

  • Table 1

    Demographic information and NIHSS scores of acute cerebral ischemia patients.

    VariableGroupP-value
    ExperimentalControl
    No. participants (males/females)18 (12/6)12 (10/2)-
    Mean age ± SD, years52.5 ± 9.7053.1 ± 6.70-
    Mean NIHSS ± SD on day 19.44 ± 2.208.50 ± 1.88-
    Mean NIHSS ± SD on day 143.72 ± 1.643.83 ± 2.12-
    DNIHSS-5.72 ± 1.93-4.67 ± 1.230.04*

    • NIHSS - National Institutes of Health Stroke Scale, ΔNIHSS - NIHSS (fourteenth day) - NIHSS (first day);

    • ↵* p<0.05, experimental group versus control group

  • Table 2

    Perfusion weighted imaging measurement results from scans taken one day and 14 days after stroke onset.

    ParameterExperimental groupControl groupP-value
    Day 1Day 14ChangeDay 1Day 14Change
    CBF(i) (10-1ml×100g-1×min-1)125.4±110.6231.7±149.0106.3±139.1194.2±182.9206.9±155.312.8±152.10.04*
    CBV(i) (10-1ml×100g-1)891.6±534.01325.2±682.5433.7±571.8878.5±358.21308.5±441.2430.0±473.90.69
    MTT(i) (10-3s)1840.7±720.01564.7±727.1-276.0±1014.11707.7±983.91946.6±1083.8238.9±544.70.02*
    TTP(i) (10-3s)3114.3±396.92941.8±197.6-172.5±423.53101.4±367.13001.6±213.0-99.9±325.10.30
    CBF(c) (10-1ml×100g-1×min-1)249.3±143.6296.8±144.947.5±165.3318.9±181.4254.6±125.4-64.4±178.60.03*
    CBV(c) (10-1ml×100g-1)1213.6±262.91418.8±474.2205.3±381.61144.1±240.71306.7±549.2162.5±416.70.38
    MTT(c) (10-3s)1289.9±525.81115.1±513.8-174.8±717.1941.1±367.11188.7±496.9247.7±410.20.02*
    TTP(c) (10-3s)2802.90±173.62721.5±172.2-81.39±222.82706.46±138.92773.33±216.966.87±196.90.03*

    • PWI - perfusion weighted imaging, CBF - cerebral blood flow, CBV - cerebral blood volume, MTT - mean transit time, TTP - time to peak, i - ipsilateral, c - contralateral,

    • ↵* p<0.05 experimental group versus control group, data expressed as mean ± standard deviation

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