Article Figures & Data
Figures
- Figure 1
- Time schedule used for our experiments: Animals were tested by apomorphine-induced rotational test and elevated body swing test (EBST) at fourth times: before stereotaxic surgery and 6-OHDA injection and in the third, fifth and eighth weeks after that. Rotational tests were performed at least 1 hour after termination of the EBST. Rotarod test, were performed in the seventh week after 6-OHDA injection. Blood sampling and measurement of its MDA concentration were performed before the surgery and in the fourth and ninth weeks after that. Pretreatments with potassium channel blockers of 4-AP and TEA and also saline was begun just before 6-OHDA injection and continued to seven days after that (black arrow). Numbers show the days after 6-OHDA injection. EBST - elevated body swing test, MDA - Malondialdehyde, 4-AP - 4-aminopyridine, TEA - Tetraethylammonium, 6-OHDA - 6-hydroxydopamine
- Figure 2
- Apomorphine- induced net contralateral rotations of different experimental groups at third (upper plot), fifth (middle plot) and eighth (lower plot) weeks post-surgery. Values are means±SE of each group. *p<0.05 and **p<0.01 compared to veh group, #p<0.05 and ##p<0.01 compared to high 4-AP group, Kruskall–Wallis nonparametric test followed by Mann–Whitney U test. 4-AP - 4-aminopyridine, TEA - Tetraethylammonium, 6-OHDA - 6-hydroxydopamine, veh - 6-OHDA + saline
- Figure 3
- Plots display results of the EBST in the third (upper plot), fifth (middle plot) and eighth (lower plot) weeks post-surgery. Values are means±SE of each group. 50% means number of left swings was equal to number of right swings. Less than 50% means that most of swings were toward left (contralateral to lesion side) and more than 50% means that most of swings were toward right side (ipsilateral to lesion side). *p<0.05 compared to veh group and #p<0.05 compared to TEA groups, Kruskall–Wallis nonparametric test followed by Mann–Whitney U test. 4-AP - 4-aminopyridine, TEA - Tetraethylammonium, 6-OHDA - 6-hydroxydopamine, veh - 6-OHDA + saline
- Figure 4
- Motor performance of different groups of rats in rotarod test examined at 3 consecutive days, 2 sessions in each. Healthy rats rapidly learned how to walk on the rotating rod and reached to maximum performance at fourth session. On the other hand, parkinsonian rats (veh) did not reach to maximum performance and showed much less learning. Learning pattern of motor performance in low TEA and 4-AP + TEA groups were very close to healthy rats while it was close to veh group in 4-AP groups and high TEA group. Values are means±SE of each group. *p<0.05, **p<0.01, ***p<0.001 compared to veh group, Kruskall–Wallis nonparametric test followed by Mann–Whitney U test. veh - 6-OHDA + saline AUC - area under the curve, for more description see the experimental procedures. R1-R6 - sessions of the test, R1 - first session, R6 - last session.
- Figure 5
- Malondialdehyde (MDA) concentrations in sera of different experimental groups. *p<0.05, **p<0.01 compared to value before 6-OHDA injection, Kruskall–Wallis nonparametric test followed by Mann–Whitney U test. 4-AP - 4-aminopyridine, TEA - Tetraethylammonium, 6-OHDA - 6-hydroxydopamine, veh - 6-OHDA + saline
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