Article Figures & Data
Figures
- Figure 1
- Comparison of total cholesterol/high-density lipoprotein cholesterol ratio among the controls and valproic acid (VPA), lamotrigine (LTG), and carbamazepine treated patients. *Significant as compared with controls (p<0.05), ∆significant as compared with LTG (p<0.05), †significant as compared with VPA (p<0.05). The line on each bar indicates standard deviation.
- Figure 2
- Comparison of low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio among the controls and valproic acid (VPA), lamotrigine (LTG), and carbamazepine treated patients. *Significant as compared with controls (p<0.05), ∆significant as compared with LTG (p<0.05), †significant as compared with VPA (p<0.05). The line on each bar indicates standard deviation.
Tables
- Table 1
Comparison of basic characteristics of the controls and patients receiving valproic acid, carbamazepine, and lamotrigine treatment.
Parameters Patients treated with different AEDs P-value Valproic acid (n=40) Carbamazepine (n=40) Lamotrigine (n=40) Controls (n=40) Duration of treatment 4.9±3.82 4.2±3.67 7.3±4.71 --- 0.01* Age 32.25±5.39 31.67±4.32 33.12±6.86 31.62±5.73 0.29 Gender Male 18 18 19 26 Female 22 22 21 14 0.89# BMI 24.71±5.36 25.21±4.10 26.27±6.18 21±2.63 <0.001* Systolic blood pressure (mm Hg) 116.12±15.72 118.0±13.37 116.0±13.51 116.8±9.30 0.64 Diastolic blood pressure (mm Hg) 76.21±10.17 76.50±8.77 75.10±9.11 73.8±7.82 0.15 - Table 2
Comparison of lipid profile among the control and valproic acid, carbamazepine, and lamotrigine treated patients.
Parameters Patients treated with different AEDs P-value Valproic acid (n=40) Carbamazepine (n=40) Lamotrigine(n=40) Controls (n=40) Total cholesterol (mg/dl) 170.7±42.17*∆ 212.7±31.89*∆† 123.1±18.72 141.5±13.31 0.001 Triglyceride (mg/dl) 153.5±43.94*∆ 203.0±48.82*∆† 119.9±25.97 140.5±18.38 0.001 HDL-c (mg/dl) 36.2±3.62* 35.7±3.51* 33.0±4.26* 41.6±3.24 0.001 LDL-c (mg/dl) 101.6±37.2*∆ 135.0±28.1*∆† 64.8±17.64 71.7±12.78 0.001 VLDL-c(mg/dl) 30.7±8.77∆ 40.9±9.59*∆† 24.1±5.18 28.2±3.52 0.001 ↵* Significant as compared with controls (p<0.05),
↵∆ significant as compared to lamotrigine (p<0.05),
↵† Significant as compared to VPA (p<0.05), AEDs - antiepileptic drugs, HDL-c - high-density lipoprotein cholesterol, LDL-c - low-density lipoprotein cholesterol,
VLDL-c - very low-density lipoprotein cholesterol
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