Research ArticleOriginal Article
Open Access

Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Ugur Lok, Umut Gulacti, Burcu Ekmekci, Taner Bulut and Murat Celik
Neurosciences Journal April 2017, 22 (2) 119-126; DOI: https://doi.org/10.17712/nsj.2017.2.20160330

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Tables

  • Table 1

    Demographic and clinical characteristics of all patients (N=250).

    Variablesn (%)
    Age (years)72.3±11.8 (35-97)
    Gender
     Female124(49.6)
     Male126(50.4)
    Co-morbidity
     Hypertension185(74.0)
     Coronary artery disease100(40.0)
     Diabetes mellitus 74(29.6)
     Cardiac heart failure 42(16.8)
     Hyperlipidemia 39(15.6)
     Chronic obstructive pulmonary disease 25(10.0)
     Other138(55.2)
     Smoking 73(29.2)
    Latency 8(2-120)
    TOAST
     Large artery disease 22 (8.8)
     Cardioembolism 29(11.6)
     Small artery disease (lacune) 40(16.0)
     Stroke of other determined0-
     Stroke of undetermined159(63.6)
    mRS
     No significant disability 46(18.4)
     Slight disability 86(34.4)
     Moderate disability 49(19.6)
     Moderate-severe disability 20 (8.0)
     Severe disability 13 (5.2)
     Dead 36(14.4)
    NIHSS 6(1-18)
    Latency (mean)(h)13.77±17.14 (2-120)
    Hospitalization days 4(1-116)
    TIV(h)4.0±9.2 (0-65 hours)
    MPV (mean)8.7 (4.4-15.7)

    • SD - standard deviation, min - minimum, max - maximum, TOAST - The Trial Of Org 10172 in Acute Stroke Treatment, mRS - modified Rankin scale, NIHSS - National Institutes of Health Stroke Scale, TIV - time interval of venipuncture, MPV - mean platelet volume

  • Table 2

    Demographic and clinical characteristics for survival status.

    VariablesAlive (n=214)Dead (n=36)P-value
    Age (years)71.7±11.875.9±11.40.049†
    Gender0.959‡
     Female106(49.5)18(50)
     Male108(50.5)18(50)
    Latency8 (2-120)5 (2-72)0.008
    NIHSS4.5 (1-16)14 (4-18)<0.001
    TOAST<0.001$
     Large artery disease22(10.3)-
     Cardioembolism27(12.6)2(5.6)
     Small artery disease (lacune)40(18.7)-
     Stroke of other determined--
    Undetermined125(58.4)34(94.4)0.494
    Hospitalization days4 (1-36)4 (1-116)0.842
    TIV(h)4.3±9.82.1±3.90.549
    MPV (mean)8.5 (4.4-13.4)8.9 (4.8-15.7)

    • ↵† Student’s t-test,

    • ↵‡ Pearson’s Chi-square test,

    • ↵ Mann-Whitney U test,

    • ↵$ Likelihood ratio test, NIHSS - National Institutes of Health Stroke Scale, TOAST - The Trial Of Org 10172 in Acute Stroke Treatment, TIV - time interval of venipuncture

  • Table 3

    The results of multiple logistic regression analysis.

    VariablesOR95% CIWaldP-value
    Age1.0430.996-1.0933.1460.076
    Latency <64.8671.652-14.3418.2390.004
    NIHSS1.5211.327-1.74536.055<0.001
    TOAST1.8341.068-3.1504.8300.028

    • OR - Odds ratio, CI - Confidence interval

  • Table 4

    Mean platelet volume levels for TOAST and Groups classifications.

    VariablesMPVP-value
    TOAST0.797
    Large artery disease8.9 (5.6-11.9)
    Cardioembolism8.5 (6.0-13.4)
    Small artery disease (lacune)8.9 (5.2-12.7)
    Stroke of other determined-
    Undetermined origin8.5 (4.4-15.7)
    Groups0.527
    Group I (mRS; 1-2-3)8.6 (4.4-13.4)
    Group II (mRS; 4-5)8.2 (5.6-12.0)
    Group III (6)8.9 (4.8-15.7)

    • Data shown as median (min-max),

    • ↵† Kruskal-Wallis test, mRS - modified Rankin scale, MPV - mean platelet volume, TOAST - The Trial Of Org 10172 in Acute Stroke Treatment

  • Table 5

    Demographical and clinical characteristics regarding for mRS classification.

    VariablesmRS 1 (n=46)mRS 2 (n=86)mRS 3 (n=49)mRS 4 (n=20)mRS 5 (n=13)mRS 6 (n=36)P-value
    Age (years)69.6±12.471.8±10.771.2±14.076.7±10.572.5±7.475.9±11.40.107†
    Gender0.040‡
     Female22(47.8)32(37.2)31(63.3)13(65)8(61.5)18(50)
     Male24(52.2)54(62.8)18(36.7)7(35)5(38.5)18(50)
    Latency8 (2-72)8.5 (3-120)8 (2-72)7.5 (3-72)8 (3-48)5 (2-72)0.087
    NIHSS2 (1-4)c,d,e,f,g4 (2-12)a,b,c,h,i8 (4-16)a,d,j,k,l11 (8-14)b,e,j,14 (8-16)f,h,k14 (4-18)g,i,l<0.001
    Hospitalization days4 (1-12)4 (1-33)4 (1-15)4 (1-16)2.5 (1-36)4 (1-116)0.394>
    TIV(h)4.1±8.65.8±12.53.6±7.91.8±3.71.5±4.12.1±3.90.201†
    MPV (mean)8.7 (5.2-12.7)8.9 (4.4-13.4)8.4 (5.4-12.3)8.2 (5.6-11.4)7.9 (6.4-12.0)8.9 (4.8-15.7)0.847

    • ↵† One-way ANOVA,

    • ↵‡ Pearson’s Chi-square test,

    • ↵ Kruskal-Wallis test,

    • ↵a - mRS 2 vs mRS 3 (p<0.05),

    • ↵b - mRS 2 vs mRS 4 (p<0.05),

    • ↵c - mRS 1 vs mRS 2 (p<0.05),

    • ↵d - mRS 1 vs mRS 3 (p<0.001),

    • ↵e - mRS 1 vs mRS 4 (p<0.001),

    • ↵f - mRS 1 vs mRS 5 (p<0.01),

    • ↵g - mRS 1 vs mRS 6 (p<0.01),

    • ↵h - mRS 2 vs mRS 5 (p<0.001),

    • ↵i - mRS 2 vs mRS 6 (p<0.001),

    • ↵j - mRS 3 vs mRS 4 (p=0.023),

    • ↵k - mRS 3 vs mRS 5 (p<0.01),

    • ↵l - mRS 3 vs mRS 6 (p<0.01), mRS - modified Rankin scale, NIHSS - National Institutes of Health Stroke Scale, TIV - time interval of venipuncture, MPV - mean platelet volume, vs – versus

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