Predictive and prognostic role of mean platelet volume in patients with first-ever acute ischemic stroke

Ugur Lok; Umut Gulacti; Burcu Ekmekci; Taner Bulut; Murat Celik

doi:10.17712/nsj.2017.2.20160330

References

↵
1. Tsai NW,
2. Chang WN,
3. Shaw CF,
4. Jan CR,
5. Chang HW,
6. Huang CR,
7. et al.
(2009) Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke. Thromb Res 124, 213–218.
Google Scholar
1. Seyhanli ES,
2. Lok U,
3. Gulacti U,
4. Buyukaslan H,
5. Atescelik M,
6. Yildiz M,
7. et al.
(2015) Assessment of serum and urine ghrelin levels in patients with acute stroke. Int J Clin Exp Med 8, 722–729.
Google Scholar
↵
1. Rodrigues B,
2. Staff I,
3. Fortunato G,
4. McCullough LD
(2014) Hyponatremia in the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis 23, 850–854.
Google Scholar
↵
1. Kamisli O,
2. Kamisli O,
3. Kablan Y,
4. Gonullu S,
5. Ozcan C
(2013) The prognostic value of an increased mean platelet volume and platelet distribution width in the early phase of cerebral venous sinus thrombosis. Clin Appl Thromb Hemost 19, 29–32.
Google Scholar
↵
1. Tombul T,
2. Atbas C,
3. Anlar O
(2005) Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. J Clin Neurosci 12, 429–434.
Google Scholar
↵
1. Zhang Z,
2. Xu X,
3. Ni H,
4. Deng H
(2014) Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 29, 885.e1–6.
Google Scholar
↵
1. Turk U,
2. Tengiz I,
3. Ozpelit E,
4. Celebiler A,
5. Pekel N,
6. Ozyurtlu F,
7. et al.
(2013) The relationship between platelet indices and clinical features of coronary artery disease. Kardiol Pol 71, 1129–1134.
Google Scholar
↵
1. Domac FM,
2. Mısırlı H,
3. Yılmaz M
(2010) Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 19, 66–72.
Google Scholar
↵
1. Pikija S,
2. Cvetko D,
3. Hajduk M,
4. Trkulja V
(2009) Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clin Neurol Neurosurg 111, 568–573.
Google Scholar
↵
1. Cerletti C,
2. Tamburrelli C,
3. Izzi B,
4. Gianfagna F,
5. de Gaetano G
(2012) Platelet-leukocyte interactions in thrombosis. Thromb Res 129, 263–266.
Google Scholar
↵
1. Kurabayashi H,
2. Kubota K,
3. Hishinuma A,
4. Majima M
(2010) Platelet activation is caused not by aging but by atherosclerosis. Arch Gerontol Geriatr 51, 205–208.
Google Scholar
↵
1. O’Malley T,
2. Langhorne P,
3. Elton RA,
4. Stewart C
(1995) Platelet size in stroke patients. Stroke 26, 995–999.
Google Scholar
↵
1. Muscari A,
2. Puddu GM,
3. Cenni A,
4. Silvestri MG,
5. Giuzio R,
6. Rosati M,
7. et al.
(2009) Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res 123, 587–591.
Google Scholar
↵
1. D’Erasmo E,
2. Aliberti G,
3. Celi FS,
4. Romagnoli E,
5. Vecci E,
6. Mazzuoli GF
(1990) Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 227, 11–14.
Google Scholar
↵
1. Butterworth RJ,
2. Bath PM
(1998) The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 9, 359–364.
Google Scholar
↵
1. Greisenegger S,
2. Endler G,
3. Hsieh K,
4. Tentschert S,
5. Mannhalter C,
6. Lalouschek W
(2004) Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 35, 1688–1691.
Google Scholar
↵
1. Dogan NO,
2. Keles A,
3. Aksel G,
4. Güler S,
5. Demircan A,
6. Bildik F,
7. et al.
(2013) Mean platelet volume as a risk stratification tool in the emergency department for evaluating patients with ischaemic stroke and TIA. J Pak Med Assoc 63, 581–584.
Google Scholar
↵
1. Furiozzi F
(1996) Mean Platelet Volume and Acute Ischemic Stroke. Stroke 27, 1010–1011.
Google Scholar
↵
1. Bath PM,
2. Butterworth RJ
(1996) Platelet size:measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7, 157–161.
Google Scholar
↵
1. Özkan B,
2. Arik OZ,
3. Gözükara MY,
4. Şahin DY,
5. Topal S,
6. Uysal OK,
7. et al.
(2016) Mean platelet volume is related with ischemic stroke in patients with sinus rhythm. Blood Coagul Fibrinolysis 27, 490–493.
Google Scholar
↵
1. Li B,
2. Liu X,
3. Cao ZG,
4. Li Y,
5. Liu TM,
6. Wang RT
(2014) Elevated mean platelet volume is associated with silent cerebral infarction. Intern Med J 44, 653–657.
Google Scholar
↵
1. Ha SI,
2. Choi DH,
3. Ki YJ,
4. Yang JS,
5. Park G,
6. Chung JW,
7. et al.
(2011) Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets 22, 408–414.
Google Scholar
↵
1. Oz II,
2. Yucel M,
3. Bilici M,
4. Şerifoğlu İ,
5. Sayın R,
6. Ilikhan SU,
7. et al.
(2016) Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis? J Stroke Cerebrovasc Dis 25, 404–409.
Google Scholar
↵
1. Tohgi H,
2. Suzuki H,
3. Tamura K,
4. Kimura B
(1991) Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke 22, 17–21.
Google Scholar
↵
1. Ntaios G,
2. Gurer O,
3. Faouzi M,
4. Aubert C,
5. Michel P
(2010) Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome. Cerebrovasc Dis 29, 484–489.
Google Scholar
↵
1. Arévalo-Lorido JC,
2. Carretero-Gómez J,
3. Álvarez-Oliva A,
4. Gutiérrez-Montaño C,
5. Fernández-Recio JM,
6. Najarro-Díez F
(2013) Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year. J Stroke Cerebrovasc Dis 22, 297–303.
Google Scholar
↵
1. Shah PA,
2. Mir RA,
3. Kamili MMA,
4. Bardi GH,
5. Masoodi ZA
(2013) Role of Mean Platelet Volume in Ischemic Stroke. JK Science 15, 136–139.
Google Scholar
↵
1. Varol E
(2014) Platelet indices in assessment of in hospital mortality in intensive care unit patients. J Crit Care 29, 864.
Google Scholar
↵
1. Bath PM
(1993) The routine measurement of platelet size using sodium citrate alone as the anticoagulant. Thromb Haemost 70, 687–690.
Google Scholar
↵
1. Endler G,
2. Klimesch A,
3. Sunder-Plassmann H,
4. Schillinger M,
5. Exner M,
6. Mannhalter C,
7. et al.
(2002) Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 117, 399–404.
Google Scholar
↵
1. Wiwanitkit V
(2013) Platelet indices and deep vein thrombosis. Clin Appl Thromb Hemost 19, 341.
Google Scholar
↵
1. Ifran A,
2. Haşimi A,
3. Kaptan K,
4. Nevruz O,
5. Beyan C,
6. Erbil K
(2005) Evaluation of platelet parameters in healthy apheresis donors using the ADVIA 120. Transfus Apher Sci 33, 87–90.
Google Scholar
↵
1. Cho SY,
2. Lee HJ,
3. Lee WI,
4. Suh JT,
5. Park TS
(2012) Large population study for the reference range of mean platelet volume in Korean individuals. Thromb Res 130, 557–558.
Google Scholar
↵
1. Lippi G,
2. Meschi T,
3. Borghi L
(2012) Mean platelet volume increases with aging in a large population study. Thromb Res 129, e159–e160.
Google Scholar
↵
1. Giovanetti TV,
2. do Nascimento AJ,
3. de Paula JP
(2011) Platelet indices:laboratory and clinical applications. Rev Bras Hematol Hemoter 33, 164–165.
Google Scholar
↵
1. Zhang Z
(2016) Multiple imputation with multivariate imputation by chained equation (MICE) package. Ann Transl Med 4, 30.
Google Scholar
1. Zhang Z
(2015) Missing data exploration:highlighting graphical presentation of missing pattern. Ann Transl Med 3, 356.
Google Scholar
↵
1. Zhang Z
(2016) Missing data imputation:focusing on single imputation. Ann Transl Med 4, 9.
Google Scholar

[1] ↵
Tsai NW,
Chang WN,
Shaw CF,
Jan CR,
Chang HW,
Huang CR,
et al.
(2009) Levels and value of platelet activation markers in different subtypes of acute non-cardio-embolic ischemic stroke. Thromb Res 124, 213–218.
Google Scholar

[2] Tsai NW,

[3] Chang WN,

[4] Shaw CF,

[5] Jan CR,

[6] Chang HW,

[7] Huang CR,

[8] et al.

[9] Seyhanli ES,
Lok U,
Gulacti U,
Buyukaslan H,
Atescelik M,
Yildiz M,
et al.
(2015) Assessment of serum and urine ghrelin levels in patients with acute stroke. Int J Clin Exp Med 8, 722–729.
Google Scholar

[10] Seyhanli ES,

[11] Lok U,

[12] Gulacti U,

[13] Buyukaslan H,

[14] Atescelik M,

[15] Yildiz M,

[16] et al.

[17] ↵
Rodrigues B,
Staff I,
Fortunato G,
McCullough LD
(2014) Hyponatremia in the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis 23, 850–854.
Google Scholar

[18] Rodrigues B,

[19] Staff I,

[20] Fortunato G,

[21] McCullough LD

[22] ↵
Kamisli O,
Kamisli O,
Kablan Y,
Gonullu S,
Ozcan C
(2013) The prognostic value of an increased mean platelet volume and platelet distribution width in the early phase of cerebral venous sinus thrombosis. Clin Appl Thromb Hemost 19, 29–32.
Google Scholar

[23] Kamisli O,

[24] Kamisli O,

[25] Kablan Y,

[26] Gonullu S,

[27] Ozcan C

[28] ↵
Tombul T,
Atbas C,
Anlar O
(2005) Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. J Clin Neurosci 12, 429–434.
Google Scholar

[29] Tombul T,

[30] Atbas C,

[31] Anlar O

[32] ↵
Zhang Z,
Xu X,
Ni H,
Deng H
(2014) Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 29, 885.e1–6.
Google Scholar

[33] Zhang Z,

[34] Xu X,

[35] Ni H,

[36] Deng H

[37] ↵
Turk U,
Tengiz I,
Ozpelit E,
Celebiler A,
Pekel N,
Ozyurtlu F,
et al.
(2013) The relationship between platelet indices and clinical features of coronary artery disease. Kardiol Pol 71, 1129–1134.
Google Scholar

[38] Turk U,

[39] Tengiz I,

[40] Ozpelit E,

[41] Celebiler A,

[42] Pekel N,

[43] Ozyurtlu F,

[44] et al.

[45] ↵
Domac FM,
Mısırlı H,
Yılmaz M
(2010) Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 19, 66–72.
Google Scholar

[46] Domac FM,

[47] Mısırlı H,

[48] Yılmaz M

[49] ↵
Pikija S,
Cvetko D,
Hajduk M,
Trkulja V
(2009) Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome. Clin Neurol Neurosurg 111, 568–573.
Google Scholar

[50] Pikija S,

[51] Cvetko D,

[52] Hajduk M,

[53] Trkulja V

[54] ↵
Cerletti C,
Tamburrelli C,
Izzi B,
Gianfagna F,
de Gaetano G
(2012) Platelet-leukocyte interactions in thrombosis. Thromb Res 129, 263–266.
Google Scholar

[55] Cerletti C,

[56] Tamburrelli C,

[57] Izzi B,

[58] Gianfagna F,

[59] de Gaetano G

[60] ↵
Kurabayashi H,
Kubota K,
Hishinuma A,
Majima M
(2010) Platelet activation is caused not by aging but by atherosclerosis. Arch Gerontol Geriatr 51, 205–208.
Google Scholar

[61] Kurabayashi H,

[62] Kubota K,

[63] Hishinuma A,

[64] Majima M

[65] ↵
O’Malley T,
Langhorne P,
Elton RA,
Stewart C
(1995) Platelet size in stroke patients. Stroke 26, 995–999.
Google Scholar

[66] O’Malley T,

[67] Langhorne P,

[68] Elton RA,

[69] Stewart C

[70] ↵
Muscari A,
Puddu GM,
Cenni A,
Silvestri MG,
Giuzio R,
Rosati M,
et al.
(2009) Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res 123, 587–591.
Google Scholar

[71] Muscari A,

[72] Puddu GM,

[73] Cenni A,

[74] Silvestri MG,

[75] Giuzio R,

[76] Rosati M,

[77] et al.

[78] ↵
D’Erasmo E,
Aliberti G,
Celi FS,
Romagnoli E,
Vecci E,
Mazzuoli GF
(1990) Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 227, 11–14.
Google Scholar

[79] D’Erasmo E,

[80] Aliberti G,

[81] Celi FS,

[82] Romagnoli E,

[83] Vecci E,

[84] Mazzuoli GF

[85] ↵
Butterworth RJ,
Bath PM
(1998) The relationship between mean platelet volume, stroke subtype and clinical outcome. Platelets 9, 359–364.
Google Scholar

[86] Butterworth RJ,

[87] Bath PM

[88] ↵
Greisenegger S,
Endler G,
Hsieh K,
Tentschert S,
Mannhalter C,
Lalouschek W
(2004) Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 35, 1688–1691.
Google Scholar

[89] Greisenegger S,

[90] Endler G,

[91] Hsieh K,

[92] Tentschert S,

[93] Mannhalter C,

[94] Lalouschek W

[95] ↵
Dogan NO,
Keles A,
Aksel G,
Güler S,
Demircan A,
Bildik F,
et al.
(2013) Mean platelet volume as a risk stratification tool in the emergency department for evaluating patients with ischaemic stroke and TIA. J Pak Med Assoc 63, 581–584.
Google Scholar

[96] Dogan NO,

[97] Keles A,

[98] Aksel G,

[99] Güler S,

[100] Demircan A,

[101] Bildik F,

[102] et al.

[103] ↵
Furiozzi F
(1996) Mean Platelet Volume and Acute Ischemic Stroke. Stroke 27, 1010–1011.
Google Scholar

[104] Furiozzi F

[105] ↵
Bath PM,
Butterworth RJ
(1996) Platelet size:measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 7, 157–161.
Google Scholar

[106] Bath PM,

[107] Butterworth RJ

[108] ↵
Özkan B,
Arik OZ,
Gözükara MY,
Şahin DY,
Topal S,
Uysal OK,
et al.
(2016) Mean platelet volume is related with ischemic stroke in patients with sinus rhythm. Blood Coagul Fibrinolysis 27, 490–493.
Google Scholar

[109] Özkan B,

[110] Arik OZ,

[111] Gözükara MY,

[112] Şahin DY,

[113] Topal S,

[114] Uysal OK,

[115] et al.

[116] ↵
Li B,
Liu X,
Cao ZG,
Li Y,
Liu TM,
Wang RT
(2014) Elevated mean platelet volume is associated with silent cerebral infarction. Intern Med J 44, 653–657.
Google Scholar

[117] Li B,

[118] Liu X,

[119] Cao ZG,

[120] Li Y,

[121] Liu TM,

[122] Wang RT

[123] ↵
Ha SI,
Choi DH,
Ki YJ,
Yang JS,
Park G,
Chung JW,
et al.
(2011) Stroke prediction using mean platelet volume in patients with atrial fibrillation. Platelets 22, 408–414.
Google Scholar

[124] Ha SI,

[125] Choi DH,

[126] Ki YJ,

[127] Yang JS,

[128] Park G,

[129] Chung JW,

[130] et al.

[131] ↵
Oz II,
Yucel M,
Bilici M,
Şerifoğlu İ,
Sayın R,
Ilikhan SU,
et al.
(2016) Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis? J Stroke Cerebrovasc Dis 25, 404–409.
Google Scholar

[132] Oz II,

[133] Yucel M,

[134] Bilici M,

[135] Şerifoğlu İ,

[136] Sayın R,

[137] Ilikhan SU,

[138] et al.

[139] ↵
Tohgi H,
Suzuki H,
Tamura K,
Kimura B
(1991) Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis. Stroke 22, 17–21.
Google Scholar

[140] Tohgi H,

[141] Suzuki H,

[142] Tamura K,

[143] Kimura B

[144] ↵
Ntaios G,
Gurer O,
Faouzi M,
Aubert C,
Michel P
(2010) Mean platelet volume in the early phase of acute ischemic stroke is not associated with severity or functional outcome. Cerebrovasc Dis 29, 484–489.
Google Scholar

[145] Ntaios G,

[146] Gurer O,

[147] Faouzi M,

[148] Aubert C,

[149] Michel P

[150] ↵
Arévalo-Lorido JC,
Carretero-Gómez J,
Álvarez-Oliva A,
Gutiérrez-Montaño C,
Fernández-Recio JM,
Najarro-Díez F
(2013) Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year. J Stroke Cerebrovasc Dis 22, 297–303.
Google Scholar

[151] Arévalo-Lorido JC,

[152] Carretero-Gómez J,

[153] Álvarez-Oliva A,

[154] Gutiérrez-Montaño C,

[155] Fernández-Recio JM,

[156] Najarro-Díez F

[157] ↵
Shah PA,
Mir RA,
Kamili MMA,
Bardi GH,
Masoodi ZA
(2013) Role of Mean Platelet Volume in Ischemic Stroke. JK Science 15, 136–139.
Google Scholar

[158] Shah PA,

[159] Mir RA,

[160] Kamili MMA,

[161] Bardi GH,

[162] Masoodi ZA

[163] ↵
Varol E
(2014) Platelet indices in assessment of in hospital mortality in intensive care unit patients. J Crit Care 29, 864.
Google Scholar

[164] Varol E

[165] ↵
Bath PM
(1993) The routine measurement of platelet size using sodium citrate alone as the anticoagulant. Thromb Haemost 70, 687–690.
Google Scholar

[166] Bath PM

[167] ↵
Endler G,
Klimesch A,
Sunder-Plassmann H,
Schillinger M,
Exner M,
Mannhalter C,
et al.
(2002) Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 117, 399–404.
Google Scholar

[168] Endler G,

[169] Klimesch A,

[170] Sunder-Plassmann H,

[171] Schillinger M,

[172] Exner M,

[173] Mannhalter C,

[174] et al.

[175] ↵
Wiwanitkit V
(2013) Platelet indices and deep vein thrombosis. Clin Appl Thromb Hemost 19, 341.
Google Scholar

[176] Wiwanitkit V

[177] ↵
Ifran A,
Haşimi A,
Kaptan K,
Nevruz O,
Beyan C,
Erbil K
(2005) Evaluation of platelet parameters in healthy apheresis donors using the ADVIA 120. Transfus Apher Sci 33, 87–90.
Google Scholar

[178] Ifran A,

[179] Haşimi A,

[180] Kaptan K,

[181] Nevruz O,

[182] Beyan C,

[183] Erbil K

[184] ↵
Cho SY,
Lee HJ,
Lee WI,
Suh JT,
Park TS
(2012) Large population study for the reference range of mean platelet volume in Korean individuals. Thromb Res 130, 557–558.
Google Scholar

[185] Cho SY,

[186] Lee HJ,

[187] Lee WI,

[188] Suh JT,

[189] Park TS

[190] ↵
Lippi G,
Meschi T,
Borghi L
(2012) Mean platelet volume increases with aging in a large population study. Thromb Res 129, e159–e160.
Google Scholar

[191] Lippi G,

[192] Meschi T,

[193] Borghi L

[194] ↵
Giovanetti TV,
do Nascimento AJ,
de Paula JP
(2011) Platelet indices:laboratory and clinical applications. Rev Bras Hematol Hemoter 33, 164–165.
Google Scholar

[195] Giovanetti TV,

[196] do Nascimento AJ,

[197] de Paula JP

[198] ↵
Zhang Z
(2016) Multiple imputation with multivariate imputation by chained equation (MICE) package. Ann Transl Med 4, 30.
Google Scholar

[199] Zhang Z

[200] Zhang Z
(2015) Missing data exploration:highlighting graphical presentation of missing pattern. Ann Transl Med 3, 356.
Google Scholar

[201] Zhang Z

[202] ↵
Zhang Z
(2016) Missing data imputation:focusing on single imputation. Ann Transl Med 4, 9.
Google Scholar

[203] Zhang Z

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