Article Figures & Data
Figures
- Figure 1
- Basic components of the neuronal network.
- Figure 2
- Basic graph theoretical parameters.
- Figure 3
- Network pathway analyses using dynamic causal modelling.
Tables
- Table 1
Data sources, parameters and characteristics of the 2 models for neuronal network analyses.
Models Data source13,24-26 Parameters35,21,25 Strenghts17-21 Weaknesses35 Utility36 Graph Theory EEG, fMRI, Histology i. Path length
ii. Clustering coefficient
iii. Centrality matrixi. Captures ictal and interictal events as intrinsic to the network.
ii. Data sets could be generated and compared with each other for validation.i. Requires separate models for effective versus functional connectivity.
ii. Analysis of effective connectivity often leads to heavy computational loadGood for assessing extent of network changes relating to the interictal state DCM fMRI, EEG i. Correlation
ii. Covariance
iii. CoherenceIncorporates directionality and therefore, effective connectivity as a basic aspect of analysis i. Assumes triggers of ictal and interictal events to be extraneous to the network under investigation.
ii. Heavily constrained by spatial and temporal resolution of data source.Good for identifying seizure onset zone fMRI - Functional magnetic resonance imaging, DCM - dynamic causal modelling, EEG-Electroencephalography
Syndrome type Structures affected1,41,43,65-68 Network changes14,62-65 Implication40,51-53 Focal epilepsy (e.g TLE) Lateral temporal, entorhinal, inferior frontal cortices, subcortical nuclei (the amygdala and medial thalamus), posterior cingulate, precuneus, inferior parietal, and medial prefrontal cortices A shift from small to world configuration towards a random configuration. a shift towards a more regular network organization. Decreased connectivity between hippocampi, decreased connectivity between the hippocampus and the orbito-frontal cortex. TLE is not restricted to the mesiotemporal lobe structures Generalized epilepsy (e.g Childhood Absence Epilepsy) Thalamo-cortical, Precuneus, posterior cingulate gyrus prefrontal cortex, temporal cortex and cerebellum Focal cortical changes in precuneus precede changes in the thalamus. Increase in connectivity in the frontal cortex, temporal cortex and the cerebellum. Preservation of normal network topology Generalized epilepsies are associated with a number of focal abnormalities. TLE- Temporal lobe epilepsy
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