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Case ReportCase Report
Open Access

Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient

Ahmad AlHaj Houssen and Fahad Algreeshah
Neurosciences Journal April 2018, 23 (2) 148-151; DOI: https://doi.org/10.17712/nsj.2018.2.20170368
Ahmad AlHaj Houssen
From the Department of Neurosurgery (AlHaj Houssen), Department of Neurology (Algreeshah), National Care Hospital, Riyadh, Kingdom of Saudi Arabia
MBBS
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  • For correspondence: [email protected]
Fahad Algreeshah
From the Department of Neurosurgery (AlHaj Houssen), Department of Neurology (Algreeshah), National Care Hospital, Riyadh, Kingdom of Saudi Arabia
MD, ABCN
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    Figure 1

    CT brain A-C) There is a well defined oval shaped at the right frontal sinus as seen in arrows (B) ethmoidal air cells suggestive of a mucocele.

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    Figure 2

    MRI brain A) Acute arterial infarction of bilateral cerebellar hemispheres (RT>>LT), cerebellar vermis, B) bilateral occipital cortex, bilateral thalami and both hippocampi midbrain as seen in arrows.

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    Figure 3

    CT brain A-B) increase cerebellar and occipital lobes hypo densities as seen in arrows, post posterior fossa decompression and extra-ventricular drain insertion

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    Table 1

    Relevant past medical history and interventions for a 33 years old male with a past medical history of nasal polyp removal and recurrent sinusitis in the last 8 years.

    DatesSummaries from initial and follow-up visitsDiagnostic testing (including dates)Interventions
    07-18/10/2016This is a case of a 33 years old male complaining of severe headache, neck pain, photophobia, vomiting and high grade fever of several days. On examination patient was conscious, GCS15/15, normal limbs power but positive Babinski signCT brain with and without contrast, Lumbar puncture, HIV, P-ANCA, C-ANCA (07-08/10/2016)Intravenous Ceftriaxon, Vancomycin, Acyclovir, Anti-tuberculus medications and Amphotricin
    19-20/10/2016Developed sever headache, dizziness, blurred of vision with right 3rd nerve palsyCT brain showed signs of increased intracranial pressure with hydrocephalus (19/10/2016)Patient seen by neurosurgery and taken immediately to operation room for external ventricular drain insertion
    21-23/10/2016Decreased level of consciousnessMRI brain with and without contrast and MRV brain showed acute multiple arterial infarctions mostly on posterior territories (21-23/10/2016)Shifted to ICU and intubated.Seen by ENT and turbinectomy was carried out and samples sent to histopathology.
    24-25/10/2016Patient developed unequal pupilsCT brain carried out showed increaswd diffuse brain edema on posterior fossa (24/10/2017)Taken immediately for urgent decompressive craniectomy
    26-30/10/2016Patient had more spikes of feverHistopathology results showed Aspergillosis species. EEG carried out to rule out any seizure showed mild to moderate encephalopathy (30/10/2017)Same management
    02-05/11/2016Patient started to be weanedNoneTracheostomy carried out
    06/11/2016Patient developed cardiac arrest then pulseless electrical activityNoneCardiopulmonary resuscitation done and patient revived
    07-08/11/2016Patient on inotropesNoneSame management
    09-10/11/2016Patient developed cardiac arrestNoneCardiopulmonary resuscitation carried out but patient died
    • HIV - Human Immunodeficiency Virus, P-ANCA - Perinuclear Anti-Neutrophil Cytoplasmic Antibodies, C-ANCA - Cytoplasmic Anti-Neutrophil Cytoplasmic Antibodies, GCS - Glasco Coma Scale, ENT - Ear, Nose, Throat

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Neurosciences Journal: 23 (2)
Neurosciences Journal
Vol. 23, Issue 2
1 Apr 2018
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Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient
Ahmad AlHaj Houssen, Fahad Algreeshah
Neurosciences Journal Apr 2018, 23 (2) 148-151; DOI: 10.17712/nsj.2018.2.20170368

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Aspergillus sinusitis complicated with meningitis and multiple cerebral infarctions in immunocompetent patient
Ahmad AlHaj Houssen, Fahad Algreeshah
Neurosciences Journal Apr 2018, 23 (2) 148-151; DOI: 10.17712/nsj.2018.2.20170368
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