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Research ArticleOriginal Article
Open Access

Stroke mimics: Clinical characteristics and outcome

Ali M. Al Khathaami, Sultan A. Alsaif, Bayan A. Al Bdah, Muath A. Alhasson, Mohammed A. Aldriweesh, Waleed A. Alluhidan, Faisal M. Almutairi, Jawaher J. Alotaibi and Mohammed A. Alskaini
Neurosciences Journal January 2020, 25 (1) 38-42; DOI: https://doi.org/10.17712/nsj.2020.1.20190096
Ali M. Al Khathaami
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS, FRCPC
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Sultan A. Alsaif
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Bayan A. Al Bdah
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
BSc
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Muath A. Alhasson
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MD
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Mohammed A. Aldriweesh
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Waleed A. Alluhidan
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Faisal M. Almutairi
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Jawaher J. Alotaibi
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MBBS
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Mohammed A. Alskaini
From King Abdulaziz Medical City (Al Khathaami, Alskaini), from King Abdullah International Medical Research Center (Al Khathaami, Alsaif, Al Bdah, Aldriweesh, Almutairi, Alotaibi), National Guard Health Affairs, from College of Medicine (Al Khathaami, Aldriweesh, Almutairi), King Saud Bin Abdulaziz University for Health Sciences, from College of Medicine (Alsaif), Almaarefa University, from Unaizah College of Medicine (Alhasson), Qassim University, and from College of Medicine (Alluhidan), Imam Mohammad Ibn Saud Islamic University, Riyadh, Kingdom of Saudi Arabia.
MD
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    Table 1

    Baseline characteristics for stroke mimic patients in comparison to stroke.

    CharacteristicsMimics
    (N=131)
    Strokes
    (N=932)
    P-value
    Mean age±SD (years)51±1560±12<0.0001
    Female sex n(%)70 (53.4)309 (33.1)<0.0001
    Medical history n(%)
    Ischemic heart disease11 (8.5)112 (12.4)0.20
    Arterial hypertension56 (43.1)645 (71.6)<0.0001
    Diabetes mellitus60 (45.8)564 (62.6)0.0005
    Dyslipidemia37 (28.5)270 (29.9)0.7
    Body Mass Index (Mean±SD)30±629±60.06
    History of smoking11 (8.5)153 (17.0)0.01
    Previous ischemic stroke/TIA†39 (30.0)238 (26.4)0.4
    Median (IQR) time from onset to arrival — Min660 (2760)540 (1500)0.2
    mRS 0 — 1 before stroke n(%)*106 (85.5)806 (88.4)0.4
    Median (IQR) NIHSS score at admission**2 (4)5 (8)<0.0001
    Treatment with tPA n(%)3 (2.3)76 (8.2)0.01
    Neurological symptoms n(%)
    Speech and language29 (22.3)369 (41.4)<0.0001
    Motor weakness62 (47.7)554 (62.2)0.7
    Sensory symptoms41 (31.5)267 (29.9)1.0
    Gait imbalance24 (18.5)231 (25.9)0.08
    • View popup
    Table 2

    Causes of stroke mimics (N=131).

    Mimicn (%)
    Peripheral vestibular disorder36 (27.4)
    Psychogenic32 (24.4)
    Unspecified14 (10.6)
    Seizure12 (9.2)
    Migraine12 (9.2)
    Metabolic/drugs12 (9.2)
    Musculoskeletal4 (3.1)
    Space occupying lesion4 (3.1)
    Peripheral vascular disease2 (1.5)
    Demyelination2 (1.5)
    Syncope1 (0.8)
    • View popup
    Table 3

    Outcome of stroke mimics compared to strokes.

    OutcomeMimics
    (N=131)
    Strokes
    (N=932)
    P-value
    In-hospital mortality3 (2.3)27 (2.9)1.0
    Dependency at discharge*17 (15.7)339 (39.8)<0.0001
    Length of stay, median (IQR)2 (2)5 (11)<0.0001
    NIHSS - national Institutes of health stroke scale, IQR - interquartile range, *Defined as modified Rankin scale >2, **Scores on the National Institutes of Health Stroke Scale (NIHSS) range from 0 (normal function) to 42 (death), with higher scores indicating a greater deficit
    • View popup
    Table 4

    Predictors of mimics among suspected strokes (multivariate logistic regression analysis).

    Independent variableOdds ratio95%CI for ORP-value
    LowerUpper
    Age0.90.950.980.0006
    Female gender1.621.022.580.04
    Medical history:
    Ischemic heart disease1.040.502.170.9
    Arterial hypertension0.370.230.61< 0.0001
    Diabetes mellitus0.990.601.650.9
    Dyslipidemia1.340.822.190.2
    Body Mass Index1.000.971.030.8
    History of smoking0.490.231.040.06
    NIHSS score at admission0.810.750.87< 0.0001
    modified Rankin Scale (mRS) before stroke <23.151.656.000.0005
    Sudden neurological symptoms:
    Speech and language0.770.461.270.3
    Motor weakness0.940.601.500.8
    Sensory symptoms1.230.762.010.3
    Gait imbalance0.730.431.260.2
    CI - confidence interval, NIHSS score - National Institutes of Health Stroke Scale scores range from 0 (normal function) to 42 (death)
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Neurosciences Journal: 25 (1)
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Stroke mimics: Clinical characteristics and outcome
Ali M. Al Khathaami, Sultan A. Alsaif, Bayan A. Al Bdah, Muath A. Alhasson, Mohammed A. Aldriweesh, Waleed A. Alluhidan, Faisal M. Almutairi, Jawaher J. Alotaibi, Mohammed A. Alskaini
Neurosciences Journal Jan 2020, 25 (1) 38-42; DOI: 10.17712/nsj.2020.1.20190096

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Stroke mimics: Clinical characteristics and outcome
Ali M. Al Khathaami, Sultan A. Alsaif, Bayan A. Al Bdah, Muath A. Alhasson, Mohammed A. Aldriweesh, Waleed A. Alluhidan, Faisal M. Almutairi, Jawaher J. Alotaibi, Mohammed A. Alskaini
Neurosciences Journal Jan 2020, 25 (1) 38-42; DOI: 10.17712/nsj.2020.1.20190096
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