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Systematic ReviewSystematic Review
Open Access

The potential role of nutritional components in improving brain function among patients with Alzheimer’s disease: a meta-analysis of RCT studies

Tarfa Albrahim
Neurosciences Journal January 2020, 25 (1) 4-17; DOI: https://doi.org/10.17712/nsj.2020.1.20190037
Tarfa Albrahim
From the College of Health and Rehabilitation Sciences, Department of Health Sciences, Clinical Nutrition, Princess Nourah Bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia.
PhD.
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Abstract

Objectives: To find out the potential role of nutritional components in improving brain function among patients with Alzheimer’s disease (AD).

Methods: The correlation between nutrition and cerebral function in cases of AD has been the focus of 19 prospective randomised controlled trials (RCTs) with a combined research sample of 2297 patients. These RCTs are subject to systematic review and meta-analysis in the current paper.

Results: Findings showed that chain-free secondary saturated fatty acids (SFA) and trans fatty acids (TFA) occurred in higher concentrations in AD patients’ brains than in controls. Furthermore, neuroinflammation was caused by remodelling of the lipid membrane and AD patients’ cognitive function was impacted by alterations in tyrosine, tryptophan, purine, and tocopherol pathway metabolomics. Moreover, in cases of mild-to-moderate AD, reduction in functionality was induced by administration of alpha-tocopherol for more than 12 months. Consumption of Souvenaid helps in synaptic synthesis, which enhances functional connectivity. Furthermore, consumption of the B vitamins folate, cobalamin and pyridoxine at dosages of 0.8 mg, 0.5 mg and 20 mg per day, respectively, over a period of one year resulted in lower plasma tHcy levels and brain atrophy.

Conclusion: Chain-free SFA and TFA occur in greater amounts in the brains of individuals with AD than in those without AD.

Footnotes

  • Disclosure. Authors have no conflict of interests, and the work was not supported or funded by any drug company.

  • Received May 20, 2019.
  • Accepted November 4, 2019.
  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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The potential role of nutritional components in improving brain function among patients with Alzheimer’s disease: a meta-analysis of RCT studies
Tarfa Albrahim
Neurosciences Journal Jan 2020, 25 (1) 4-17; DOI: 10.17712/nsj.2020.1.20190037

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The potential role of nutritional components in improving brain function among patients with Alzheimer’s disease: a meta-analysis of RCT studies
Tarfa Albrahim
Neurosciences Journal Jan 2020, 25 (1) 4-17; DOI: 10.17712/nsj.2020.1.20190037
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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