Research ArticleOriginal Article
Open Access

Corpus callosum index correlates with brain volumetry and disability in multiple sclerosis patients

Stefanus E. Sugijono, Rahmad Mulyadi, Salsabila Firdausia, Joedo Prihartono and Riwanti Estiasari
Neurosciences Journal July 2020, 25 (3) 193-199; DOI: https://doi.org/10.17712/nsj.2020.3.20190093

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    Measurement of CCI using method proposed by Figuera et al. The anterior segment is represented by aa’, the posterior by bb’ and cc’ corresponds to the medium segment. The CC was acquired by normalizing the 3 segments by the farthest anteroposterior segment (ab).

  • Figure 2
    Figure 2

    Correlation between CCI with A) Corpus Callosum volume, B) Cortical Grey Matter volume, C) Subcortical Grey Matter Volume and D) Cerebral White Matter volume

Tables

  • Table 1

    Clinical Characteristics, brain volumetry, and corpus callosum index measurement

    VariablesN=30
    Clinical Characteristics
    Gender - N(%)
    Male6 (20)
    Female24 (80)
    MS subtype–N(%)
    RRMS22 (73.3)
    SPMS8 (26.7)
    Age (years)–Median (range)32 (20-61)
    Age of onset (years)–Median (range)26 (15-52)
    Relapse frequency (times/year)–Median (range)4.5 (1-12)
    EDSS–Median (range)3.5 (0-8)
    Brain volumetry (mm3) and CCI
    Corpus Callosum volume–Mean (SD)2233.6 (696.3)
    Cortical gray matter volume–Mean (SD)379396.8 (42044.9)
    Subcortical gray matter volume–Mean (SD)44717.7 (6818.8)
    White matter volume -Mean (SD)354678.8 (66998.5)
    Corpus Callosum Index–Mean (SD)0.31 (0.07)
  • Table 2

    The SPMS subjects had higher EDSS and smaller CCV and CCI.

    VariablesRRMS (N=22) Median (range)SPMS (N=8) Median (range)*p-value
    Age of onset29.5 (17-52)23.5 (15-28)0.06
    EDSS3 (0-7)6 (3.5-8)0.003
    CCV2459.35 (1446.3-2306.1)1729 (617.8-1924)0.0004
    CCI0.33 (0.19-0.44)0.24 (0.21-0.28)0.008

    • ↵* Mann Whitney U test

    • EDSS - Extended Disability Status Scale

    • CCV - Corpus Callosum Volume

    • CCI - Corpus Callosum Index

    • RRMS - Relapsing Remitting Multiple Sclerosis

    • SPMS - Secondary Progressive Multiple Sclerosis

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