Frequency of antiepileptic drugs and response change in pediatric patients receiving 2 or more antiepileptic drugs

↵* When classifying AEDs, the following criteria were used: AEDs that were in clinical use before 1993 were considered to be older generation antiepileptic drugs, which include carbamazepine, phenytoin phenobarbital, ethosuximide, primidone, clonazepam, and valproic acid. While, AEDs approved for clinical use after 1993 were considered newer-generation drugs, including tiagabine, felbamate, gabapentin, oxcarbazepine, zonisamide, lamotrigine, topiramate, and levetiracetam16

↵* The following adverse drug reactions were reported by only one patient: cognitive impairment, constipation, drooling, increased appetite, increased blood pressure, increased heart rate, psychomotor slowing,shortness of breath, tremor, and urinary incontinence. Some patients reported more than one adverse drug reaction at a time