Research ArticleOriginal Article
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Consanguinity in patients with mesial temporal lobe epilepsy due to hippocampal sclerosis in a Saudi population

Khalid S. Alqadi, Saba A. Rammal, Mosaab E. Alam, Ashwaq M. Alshahrani, Saleh S. Baeesa, Husam R. Kayyali, Fawzi A. Babtain and Youssef A. Al-Said
Neurosciences Journal August 2020, 25 (4) 276-280; DOI: https://doi.org/10.17712/nsj.2020.4.20200055

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Tables

  • Table 1

    Chi-square and risk estimate.

    Patients with HSOdds ratio- 95% CIP-value
    Consanguinity 1st and 2nd cousins2.037 (0.943 - 4.40)0.052
    First cousin1.400 (0.630 - 3.11)0.417
    Second cousin2.698 (0.840 - 8.66)0.117
    HS: hippocampal sclerosis
  • Table 2

    Characteristics of 120 patients.

    VariablesHS group (n=40)Control group (n=80)
    Gender
    Male2645
    Female1435
    Mean age at onset (range)11.5 years (1-36)13 years (1-50)
    Mean age at diagnosis (range)30 years (15-54)31 years (9-68)
    Parental consanguinity22 (55.0)30 (37.5)
    First cousin15 (68.0)24 (80.0)
    Second cousin7 (32.0)6 (20.0)
    History of febrile seizure8 (19.5)9 (11.0)
    The family history of epilepsy11 (28.0)26 (32.0)
    Seizure freedom *26 (65.0)34 (42.5)
    HS: hippocampal sclerosis, * Seizure freedom after epilepsy surgery in HS group and seizure control in patients with cryptogenic epilepsy at the time of conducting the study
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