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Research ArticleOriginal Articles
Open Access

Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center

Fahad A. Bashiri, Matar A. Al-Sehemi, Muddathir H. Hamad, Nawaf R. Alshammari, Mujtaba A Aljumah, Amal Kentab and Mustafa A. Salih
Neurosciences Journal January 2021, 26 (1) 21-25; DOI: https://doi.org/10.17712/nsj.2021.1.20200087
Fahad A. Bashiri
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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  • For correspondence: [email protected]
Matar A. Al-Sehemi
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Muddathir H. Hamad
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Nawaf R. Alshammari
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Mujtaba A Aljumah
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Amal Kentab
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Mustafa A. Salih
From the Division of Pediatric Neurology (Bashiri, Al-Sehemi, Hamad, Aljumah, Kentab, Salih), Department of Pediatrics (Alshammari), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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    Table 1

    Demographic Characteristics.

    EtiologyUnknownCryptogenicSymptomaticTotal
    Gender
     Male4 (7.5)2 (3.7)18 (34)24 (45.2)
     Female4 (7.5)5 (9.5)20 (37.8)29 (54.8)
    Age at onset of spasms (months)7.88.07.47.8
    Age at start of treatment (months)8.59.68.89.0
    Delay in treatment (months)0.721.61.41.3
    • View popup
    Table 2

    Etiological Categorization.

    Etiologyn(%)
     Unknown8(15.1)
     Cryptogenic7(13.2)
    Symptomatic38(71.7)
     Perinatal asphyxia9(17)
     CNS malformation10(18.9)
     Tuberous sclerosis5(9.4)
     Metabolic3(5.7)
     Chromosomal anomaly5(9.4)
     Hypomelanosis of Ito2(3.8)
    Other4(7.5)
    Total53(100.0)
    • View popup
    Table 3

    Neurodevelopmental outcomes.

    MeasurementEpilepsyMotorCognitive
    Good outcomePoor outcomeP-valueGood outcomePoor outcomeP-valueGood outcomePoor outcomeP-value
    Etiology0.3140.003*0.001*
     Unknown7 (13.2)1 (1.9)7 (13.2)1 (1.9)7(13.2)1 (1.9)
     Cryptogenic4 (7.5)3 (5.7)2 (3.8)5 (9.4)1 (1.9)6 (11.3)
     Symptomatic24 (45.3)14 (26.4)9 (17)29 (54.7)7 (13.2)31 (58.5)
    Gender0.5020.5020.272
     Male17 (70.8)7 (29.2)7 (70.8)17 (29.2)5 (20.8)19 (79.2)
     Female18 (62.0)11 (38.0)11 (38.0)18 (62.0)10 (34.5)19 (65.5)
    Age at onset of spasms (months)6.3010.200.1387.397.630.8986.877.820.628
    Delay in treatment (months)0.821.640.1160.441.410.010*0.401.360.006*
    • ↵* Statistically significant

    • View popup
    Table 4

    Initial treatment.

    Initial therapyn(%)
    ACTH/Prednisolone6(11.32)
    Vigabatrin18(33.96)
    Combination therapy20(37.73)
    ACTH/Prednisolone/Vigabatrin + Other9(16.98)
    • View popup
    Table 5

    Response to treatment and outcome.

    Response to treatmentGood Epilepsy OutcomeGood Motor OutcomeGood Cognitive Outcome
    ACTH/Prednisolone4 (8.3)1 (2.1)0 (0)
    Vigabatrin13 (20.8)9 (10.4)5 (8.3)
    Combination therapy16 (33.3)9 (18.8)7 (14.6)
    ACTH/Prednisolone/Vigabatrin + Other3 (4.2)1 (2.1)2 (2.1)
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Neurosciences Journal: 26 (1)
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Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center
Fahad A. Bashiri, Matar A. Al-Sehemi, Muddathir H. Hamad, Nawaf R. Alshammari, Mujtaba A Aljumah, Amal Kentab, Mustafa A. Salih
Neurosciences Journal Jan 2021, 26 (1) 21-25; DOI: 10.17712/nsj.2021.1.20200087

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Neurodevelopmental and epilepsy outcomes of patients with infantile spasms treated in a tertiary care center
Fahad A. Bashiri, Matar A. Al-Sehemi, Muddathir H. Hamad, Nawaf R. Alshammari, Mujtaba A Aljumah, Amal Kentab, Mustafa A. Salih
Neurosciences Journal Jan 2021, 26 (1) 21-25; DOI: 10.17712/nsj.2021.1.20200087
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