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Tables
- Table 1
- Demographic and baseline characteristics of patients treated with IV tissue-type plasminogen activator (tPA) in low dose and standard dose groups.
Items Low dose (n=40) Standard dose (n=40) Total (n=80) x2 P-value Age Mean± SD 60.58±14.16 61.03±8.49 60.80±11.60 t=0.17 0.864 Gender Males 22 (55.0) 30 (75.0) 52 (65.0) X2 =3.52 0.061 Females 18 (45.0) 10 (25.0) 28 (35.0) Current smokers 16 (40.0) 21 (52.5) 37 (46.3) 1.26 0.262 Hypertension 26 (65.0) 26 (65.0) 52 (65.0) -- -- Diabetes mellitus 19 (47.5) 12 (30.0) 31 (38.8) 2.58 0.108 Dyslipidemia 14 (35.0) 15 (37.5) 29 (36.2) 0.49 0.485 Previous stroke 5 (12.5) 4 (10.0) 9 (11.3) 0.13 0.723 AF 12 (30.0) 6 (15.0) 18 (22.5) 2.58 0.108 IHD 12 (30.0) 13 (32.5) 25 (31.3) 0.06 0.809 NIHSS on admission (Mean± SD) 12.58±4.37 14.03±4.17 13.30±4.31 t=1.52 0.133 Time to treatment (hours) 0-3 4 (10.0) 39 (97.5) 43 (53.8) X2=61.60 <0.001* 3-4.5 36 (90.0) 1 (2.5) 4 (5.0) Previous treatment Antiplatelet drugs 12 (30.0) 3 (7.5) 15 (18.8) 3.22 0.023* Warfarin anticoagulant 4 (10.0) 2 (5.0) 6 (7.5) 0.72 0.396 Prestroke mRS 34 (85.0) 35 (87.5) 69 (86.0) 0.88 0.644 Score 0 2 (5.0) 3 (7.5) 5 (6.0) Score 1 4 (10.0) 2 (5.0) 6 (7.5) Score 2 Early signs of ischemia 6 (15.0) 4 (10.0) 10 (12.5) 0.46 0.499 ASPECT score (Mean±SD) 6.83±3.09 5.55±2.59 6.19±2.90 U=2.00 0.049* TOAST classification 12 (30.0) 7 (17.5) 19 (23.8) 1.73 0.189 Cardio embolic 18 (45.0) 14 (35.0) 32 (40.0) 0.83 0.361 Lacunar 14 (35.0) 9 (22.5) 23 (28.8) 1.53 0.217 Large artery 1 (2.5) 1 (1.3) 1.01 0.314 Other determined 1 (2.5) 4 (10.0) 5 (6.3) 1.92 0.166 Undetermined Oxfordshire classification 14 (35.0) 15 (37.5) 29 (36.3) 0.05 0.816 LACI 13 (32.5) 16 (40.0) 29 (36.3) 0.49 0.485 PACI 8 (20.0) 0 8 (10.0) 8.89 0.003* POCI 5 (12.5) 9 (22.5) 14 (17.5) 1.39 0.239 TACI Values are presented as number and percentage (%). AF - atrial fibrillation, IHD: ischemic heart disease, NIHSS: National Institute of Health Stroke Scale, mRS - modified rankin scale, ASPECT - Alberta Stroke Program Early CT Score, U - Mann-Whitney test, TOAST - Trial of ORG 10172 in Acute Stroke Treatment, LACI - lacunar infarction, PACI - partial anterior circulation infarction, TACI - total anterior circulation infarction,POCI - posterior circulation infarction
- Table 2
- Comparison between low dose and standard dose Alteplase treated acute ischemic stroke patients regarding hemorrhagic transformation after treatment.
Items Low dose (n=40) Standard dose (n=40) Total x2 P-value Hemorrhagic transformation 1 (2.5) 5 (12.5) 6 (7.5) 2.88 0.090 Symptomatic ICH 0 3 (7.5) 3 (3.8) 3.12 0.077 Asymptomatic ICH 1 (2.5) 2 (5.0) 3 (3.8) 0.35 0.556 Parenchymal hemorrhage 1 1 (2.5) 2 (5.0) 3 (3.8) 0.35 0.556 Parenchymal hemorrhage 2 0 3 (7.5) 3 (3.8) 3.12 0.077 Values are presented as number and percentage (%). ICH - intracranial hemorrhage
- Table 3
- Comparison between low dose and standard dose Alteplase treated acute ischemic stroke patients regarding their outcome of treatment assessed by modified rankin scale (mRS) at 3 months and prevalence of deaths.
Items Low dose (n=40) Standard dose (n=40) Total (n=80) x2 P-value Outcome Favorable 27 (67.5) 25 (62.5) 52 (65.0) 0.23 0.631 Death In hospital 1 (2.5) 1 (2.5) 2 (2.5) -- --- Within 3 months 2 (0.5) 1 (2.5) 3 (3.8) 0.35 0.556 Overall deaths 3 (7.5) 2 (5.0) 5 (6.3) 0.21 0.644 Values are presented as number and percentage (%). Favorable outcome: mRS from 0-2
- Table 4
- Binary logistic regression analysis for predictors of favorable outcome at 3 months.
Variables B P-value OR 95% CI Lower Upper Age -0.041 0.347 0.960 0.881 1.046 Gender (male) 1.209 0.307 3.352 0.329 34.195 DM 1.032 0.288 2.806 0.418 18.845 HTN -1.098 0.143 0.333 0.077 1.449 Smoking 0.037 0.972 1.038 0.130 8.312 Dyslipidemia -1.364 0.094 0.256 0.052 1.260 Previous stroke 0.535 0.804 1.707 0.025 115.316 AF 20.969 1.000 127.287 0.000 - IHD -0.081 0.929 0.923 0.157 5.429 Single antiplatelets 2.592 0.082 13.360 0.718 248.528 Double antiplatelets 0.503 0.783 1.654 0.046 59.316 Anticoagulant -0.953 0.549 0.386 0.017 8.686 Time window 3 hours 2.271 0.089 9.684 0.707 132.667 tPA (0.9) -0.912 0.504 0.402 0.028 5.824 NIHSS (≤13) -2.338 0.018 0.097 0.014 0.673 Sign ischemia (1) 1.821 0.129 6.179 0.587 65.051 Old stroke -1.867 0.334 0.155 0.004 6.800 TOAST (cardioembolic) -18.096 1.000 0.000 0.000 - TOAST (lacunar) 24.512 0.999 44183383884.966 0.000 - TOAST (large artery) 3.084 0.151 21.849 0.326 1463.972 TOAST(other determined) -19.249 1.000 0.000 0.000 - Oxford (LACI) -21.197 0.999 0.000 0.000 - Oxford (PACI) 1.897 0.179 6.666 0.419 106.126 Oxford (POCI) -19.361 0.999 0.000 0.000 - Symptom Hg -20.131 0.999 0.000 0.000 - B - beta coefficient, OR - odd’s ratio, CI - confidence interval, ICH - intracranial hemorrhage, DM - diabetes mellitus,HTN - hypertension, AF - atrial fibrillation, IHD - ischemic heart disease, NIHSS - National Institute of health stroke scale,TOAST - Trial of ORG 10172 in Acute Stroke Treatment, LACI - lacunar infarction, PACI - partial anterior circulation infarction,POCI - posterior circulation infarction, tPA - Tissue-type plasminogen activator
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