Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • Saudi Medical Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Neurosciences Journal
  • Other Publications
    • Saudi Medical Journal
  • My alerts
  • Log in
Neurosciences Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Articles
Open Access

Low versus standard dose intravenous alteplase in the treatment of acute ischemic stroke in Egyptian patients

Gelan M. Salem, Wafik M. El-Sheik, Basma G. El-shanawany and Khaled H. Afifi
Neurosciences Journal April 2021, 26 (2) 179-185; DOI: https://doi.org/10.17712/nsj.2021.2.20200148
Gelan M. Salem
From the Neuro-Psychiatry Department (Salem, El-Sheik, Afifi), Menoufia University, Menoufia; from the Mataria Teaching Hospital (El-shanawany), Mataria, Egypt,
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wafik M. El-Sheik
From the Neuro-Psychiatry Department (Salem, El-Sheik, Afifi), Menoufia University, Menoufia; from the Mataria Teaching Hospital (El-shanawany), Mataria, Egypt,
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Basma G. El-shanawany
From the Neuro-Psychiatry Department (Salem, El-Sheik, Afifi), Menoufia University, Menoufia; from the Mataria Teaching Hospital (El-shanawany), Mataria, Egypt,
MBBCH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Khaled H. Afifi
From the Neuro-Psychiatry Department (Salem, El-Sheik, Afifi), Menoufia University, Menoufia; from the Mataria Teaching Hospital (El-shanawany), Mataria, Egypt,
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Macrez R,
    2. Ali C,
    3. Toutirais O,
    4. Le Mauff B,
    5. Defer G,
    6. Dirnagl U, et al.
    Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurology 2011; 10: 471–480.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    National Institute of Neurological Disorders and Stroke rt-PA Stroke Study. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333: 1581–1587.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Wahlgren N,
    2. Ahmed N,
    3. Dávalos A,
    4. Ford GA,
    5. Grond M,
    6. Hacke W, et al.
    Thrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of Thrombolysis in Stroke- Monitoring Study (SITS-MOST): an observational study. Lancet 2007; 369: 275–282.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Hacke W,
    2. Kaste M,
    3. Bluhmki E,
    4. Brozman M,
    5. Dávalos A,
    6. Guidetti D, et al.
    Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke (ECASS III). N Engl J Med 2008; 359: 1317–1329.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Chiu D,
    2. Krieger D,
    3. Villar-Cordova C,
    4. Kasner SE,
    5. Morgenstern LB,
    6. Bratina PL, et al.
    Intravenous tissue plasminogen activator for acute ischemic stroke: feasibility, safety, and efficacy in the first year of clinical practice. Stroke 1998; 29: 18–22.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Liu MD,
    2. Ning WD,
    3. Wang RC,
    4. Chen W,
    5. Yang Y,
    6. Lin Y, et al.
    Low-dose versus standard-dose tissue plasminogen activator in acute ischemic stroke in Asian populations: a meta-analysis. Medicine 2015; 94: e2412.
    OpenUrlPubMed
  7. 7.↵
    1. Yamaguchi T,
    2. Mori E,
    3. Minematsu K,
    4. Nakagawara J,
    5. Hashi K,
    6. Saito I et al
    : Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke 2006; 37: 1810–1815.
    OpenUrlAbstract/FREE Full Text
  8. 8.
    1. Nakagawara J,
    2. Minematsu K,
    3. Okada Y,
    4. Tanahashi N,
    5. Nagahiro S,
    6. Mori E, et al.
    Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: the Japan post-Marketing Alteplase Registration Study (J-MARS). Stroke 2010; 41: 1984–1989.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Mori E,
    2. Yoneda Y,
    3. Tabuchi M,
    4. Yoshida T,
    5. Ohkawa S,
    6. Ohsumi Y, et al.
    Intravenous recombinant tissue plasminogen activator in acute carotid artery territory stroke. Neurology 1992; 42: 976–976.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Yamaguchi T,
    2. Mori E,
    3. Minematsu K,
    4. Nakagawara J,
    5. Hashi K,
    6. Saito I, et al.
    Alteplase at 0.6 mg/kg for acute ischemic stroke within 3 hours of onset: Japan Alteplase Clinical Trial (J-ACT). Stroke 2006; 37: 1810–1815.
    OpenUrlAbstract/FREE Full Text
  11. 11.
    1. Abd Allah F,
    2. Baligh E,
    3. Ibrahim M
    . Clinical relevance of carotid atherosclerosis among Egyptians: a 5-year retrospective analysis of 4,733 subjects. Neuroepidemiology 2010; 35: 275–27s9.
    OpenUrlCrossRefPubMed
  12. 12.
    1. Zakaria MF,
    2. Aref H,
    3. Abd ElNasser A,
    4. Fahmy N,
    5. Tork M,
    6. Fouad M, et al.
    Egyptian experience in increasing utilization of reperfusion therapies in acute ischemic stroke. Int J Stroke 2018; 13: 525–529.
    OpenUrl
  13. 13.↵
    1. Powers WJ,
    2. Rabinstein AA,
    3. Ackerson, T., et al.
    2018 guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2018; 49: e46–e99.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Barber PA,
    2. Demchuk AM,
    3. Zhang J,
    4. Adeoye OM,
    5. Bambakidis NC,
    6. Becker K, et al.
    The validity and reliability of a novel quantitative CT score in predicting outcome in hyperacute stroke prior to thrombolytic therapy. Lancet 2000; 355: 1670–1674.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Bamford J,
    2. Sandercock P,
    3. Dennis M,
    4. Burn J,
    5. Warlow C
    . Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991; 337: 1521–1526.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Adams H,
    2. Bendixen B,
    3. Kappelle L
    . Classification of subtype of acute ischemic stroke Definitions for use in a multicenter clinical trial. TOAST Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993; 24: 35–41.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Hage V
    . “The NIH stroke scale: a window into neurological status”. Nursing Spectrum 2011; 24: 44–49.
    OpenUrl
  18. 18.↵
    1. Kim B J,
    2. Han MK,
    3. Park TH,
    4. Park SS,
    5. Lee KB,
    6. Lee BC, et al.
    Low-versus standard-dose alteplase for ischemic strokes within 4.5 hours: a comparative effectiveness and safety study. Stroke 2015; 46: 2541–2548.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Chao AC,
    2. Liu CK,
    3. Chen CH,
    4. Lin HJ,
    5. Liu CH,
    6. Jeng JS, et al.
    Different doses of recombinant tissue-type plasminogen activator for acute stroke in Chinese patients. Stroke 2014; 45: 2359–2365.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Anderson CS,
    2. Robinson T,
    3. Lindley RI,
    4. Arima H,
    5. Lavados PM,
    6. Lee T, et al.
    Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke. N Engl J Med 2016; 374: 2313–2323.
    OpenUrlPubMed
  21. 21.↵
    1. Nguyen TH,
    2. Truong AL,
    3. Ngo MB,
    4. Bui CT,
    5. Dinh QV,
    6. Doan TC, et al.
    Patients with thrombolysed stroke in Vietnam have an excellent outcome: results from the Vietnam Thrombolysis Registry. Eur J Neurol 2010; 17: 1188–1192.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Sharma VK,
    2. Kawnayn G,
    3. Sarkar N
    . Acute ischemic stroke: comparison of low-dose and standard-dose regimes of tissue plasminogen activator. Expert Rev Neurother 2013; 13: 895–902.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Yang J,
    2. Yu F,
    3. Liu H,
    4. An H,
    5. Xiong R,
    6. Huang D
    . A retrospective study of thrombolysis with 0.6 mg/kg recombinant tissue plasminogen activator (rt-PA) in mild stroke. Sci Rep 2016; 6: 31344.
    OpenUrl
  24. 24.↵
    1. Zhou XY,
    2. Wanga SS,
    3. Collins ML,
    4. Davis SM,
    5. Yan B
    . Efficacy and safety of different doses of intravenous tissue plasminogen activator in Chinese patients with ischemic stroke. J Clin Neurosci 2010; 17: 988–992.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Zakaria MF,
    2. Aref H,
    3. Abd ElNasser A,
    4. Fahmy N,
    5. Tork MA,
    6. Fouad MM, et al.
    Egyptian experience in increasing utilization of reperfusion therapies in acute ischemic stroke. Int J Stroke 2018; 13: 525–529.
    OpenUrl
PreviousNext
Back to top

In this issue

Neurosciences Journal: 26 (2)
Neurosciences Journal
Vol. 26, Issue 2
1 Apr 2021
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Neurosciences Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Low versus standard dose intravenous alteplase in the treatment of acute ischemic stroke in Egyptian patients
(Your Name) has sent you a message from Neurosciences Journal
(Your Name) thought you would like to see the Neurosciences Journal web site.
Citation Tools
Low versus standard dose intravenous alteplase in the treatment of acute ischemic stroke in Egyptian patients
Gelan M. Salem, Wafik M. El-Sheik, Basma G. El-shanawany, Khaled H. Afifi
Neurosciences Journal Apr 2021, 26 (2) 179-185; DOI: 10.17712/nsj.2021.2.20200148

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Low versus standard dose intravenous alteplase in the treatment of acute ischemic stroke in Egyptian patients
Gelan M. Salem, Wafik M. El-Sheik, Basma G. El-shanawany, Khaled H. Afifi
Neurosciences Journal Apr 2021, 26 (2) 179-185; DOI: 10.17712/nsj.2021.2.20200148
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods.
    • Results.
    • Discussion.
    • Acknowledgment.
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Assessment of the stroke-specific quality-of-life scale in KFHU, Khobar
  • Impact of COVID-19 on the rate of stroke cases at a tertiary hospital in Makkah, Saudi Arabia
  • Public Awareness of Ischemic Stroke in Medina city, Kingdom of Saudi Arabia
Show more Original Articles

Similar Articles

Navigate

  • home

More Information

  • Help

Additional journals

  • All Topics

Other Services

  • About

© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

Powered by HighWire